How human respiratory physiology and the transport phenomena associated with inhaled
airflow in the upper airway proceed to impact transmission of SARS-CoV-2, leading to the …

The objectives of this study were to expand and implement a Computational Fluid Dynamics
(CFD)-Dissolution, Absorption and Clearance (DAC)-Pharmacokinetics (PK) multi-physics …

Abstract Evaluation of the regional intranasal delivery of locally acting drugs in children is
challenging. Anatomical nasal airway replicas potentially can provide a robust pre-clinical …

Background Accurate methods are needed to evaluate the anatomy of the internal nasal
valve (INV), yet there is currently no ideal measurement technique. Our systematic review …

Nasal sprays, which produce relatively large pharmaceutical droplets and have high
momentum, are primarily used to deliver locally acting drugs to the nasal mucosa …

The nasopharynx, at the back of the nose, constitutes the dominant initial viral infection
trigger zone along the upper respiratory tract. However, as per the standard recommended …

Quantifying drug delivery to the site of action using locally-acting nasal suspension sprays is
a challenging but important step toward understanding bioequivalence (BE) between test …

In vitro nasal models can potentially facilitate development and approval of nasal drug
products. This study aims to evaluate the potential for using regional deposition …

Momentum transfer from nasal spray droplets to the surrounding gas may create droplet
cloud motion and influence nasal deposition patterns. The objective of this study was to …

To improve the relationships between commonly conducted in vitro studies for locally-acting
nasal spray drug products with in vivo regional deposition, this study developed a set of in …