Mass-spectrometric exploration of proteome structure and function
Numerous biological processes are concurrently and coordinately active in every living cell.
Each of them encompasses synthetic, catalytic and regulatory functions that are, almost …
Each of them encompasses synthetic, catalytic and regulatory functions that are, almost …
Peptidomics
Peptides are biopolymers, typically consisting of 2–50 amino acids. They are biologically
produced by the cellular ribosomal machinery or by non-ribosomal enzymes and …
produced by the cellular ribosomal machinery or by non-ribosomal enzymes and …
Discovery of human signaling systems: pairing peptides to G protein-coupled receptors
The peptidergic system is the most abundant network of ligand-receptor-mediated signaling
in humans. However, the physiological roles remain elusive for numerous peptides and …
in humans. However, the physiological roles remain elusive for numerous peptides and …
[HTML][HTML] Recent advances in hydrophilic interaction liquid interaction chromatography materials for glycopeptide enrichment and glycan separation
G Qing, J Yan, X He, X Li, X Liang - TrAC Trends in Analytical Chemistry, 2020 - Elsevier
Glycosylation is one of the most common and important types of protein post-translational
modifications in mammalian cells. To decode the protein glycosylation, it is highly important …
modifications in mammalian cells. To decode the protein glycosylation, it is highly important …
Peptidomics: A review of clinical applications and methodologies
Improvements in both liquid chromatography (LC) and mass spectrometry (MS)
instrumentation have greatly enhanced proteomic and small molecule metabolomic analysis …
instrumentation have greatly enhanced proteomic and small molecule metabolomic analysis …
Combining mass spectrometry and machine learning to discover bioactive peptides
CT Madsen, JC Refsgaard, FG Teufel… - Nature …, 2022 - nature.com
Peptides play important roles in regulating biological processes and form the basis of a
multiplicity of therapeutic drugs. To date, only about 300 peptides in human have confirmed …
multiplicity of therapeutic drugs. To date, only about 300 peptides in human have confirmed …
Peptide clustering enhances large-scale analyses and reveals proteolytic signatures in mass spectrometry data
E Hartman, F Forsberg, S Kjellström, J Petrlova… - Nature …, 2024 - nature.com
Recent advances in mass spectrometry-based peptidomics have catalyzed the identification
and quantification of thousands of endogenous peptides across diverse biological systems …
and quantification of thousands of endogenous peptides across diverse biological systems …
[HTML][HTML] Large-scale discovery of non-conventional peptides in maize and Arabidopsis through an integrated peptidogenomic pipeline
Abstract Non-conventional peptides (NCPs), which include small open reading frame-
encoded peptides, play critical roles in fundamental biological processes. In this study, we …
encoded peptides, play critical roles in fundamental biological processes. In this study, we …
An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles
Peptide hormones and neuropeptides encompass a large class of bioactive peptides that
regulate physiological processes like anxiety, blood glucose, appetite, inflammation and …
regulate physiological processes like anxiety, blood glucose, appetite, inflammation and …
Peptidomic analysis reveals seasonal neuropeptide and peptide hormone changes in the hypothalamus and pituitary of a hibernating mammal
During the winter, hibernating mammals undergo extreme changes in physiology, which
allow them to survive several months without access to food. These animals enter a state of …
allow them to survive several months without access to food. These animals enter a state of …