Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

B Niu, K Liao, Y Zhou, T Wen, G Quan, X Pan, C Wu - Biomaterials, 2021 - Elsevier
Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a
high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) …

Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Y **ong, C **ao, Z Li, X Yang - Chemical Society Reviews, 2021 - pubs.rsc.org
Glutathione (GSH), the main redox buffer, has long been recognized as a pivotal modulator
of tumor initiation, progression and metastasis. It is also implicated in the resistance of …

Guiding transition metal‐doped hollow cerium tandem nanozymes with elaborately regulated multi‐enzymatic activities for intensive chemodynamic therapy

S Dong, Y Dong, B Liu, J Liu, S Liu, Z Zhao… - Advanced …, 2022 - Wiley Online Library
Clinical applications of nanozyme‐initiated chemodynamic therapy (NCDT) have been
severely limited by the poor catalytic efficiency of nanozymes, insufficient endogenous …

Glutathione-depleting nanomedicines for synergistic cancer therapy

X Cheng, HD Xu, HH Ran, G Liang, FG Wu - ACS nano, 2021 - ACS Publications
Cancer cells frequently exhibit resistance to various molecular and nanoscale drugs, which
inevitably affects the drugs' therapeutic outcomes. Overexpression of glutathione (GSH) has …

Recent advances on endogenous/exogenous stimuli-triggered nanoplatforms for enhanced chemodynamic therapy

Q Sun, Z Wang, B Liu, F He, S Gai, P Yang… - Coordination Chemistry …, 2022 - Elsevier
In view of certain unique internalization features of the tumor microenvironment
(TME)(mainly including hypoxia, acidity and higher concentrations of H 2 O 2 and GSH) …

A Fluorinated BODIPY-Based Zirconium Metal–Organic Framework for In Vivo Enhanced Photodynamic Therapy

X Chen, BB Mendes, Y Zhuang, J Conniot… - Journal of the …, 2024 - ACS Publications
Photodynamic therapy (PDT), an emergent noninvasive cancer treatment, is largely
dependent on the presence of efficient photosensitizers (PSs) and a sufficient oxygen …

Metal–organic frameworks meet polymers: from synthesis strategies to healthcare applications

AK Bindra, D Wang, Y Zhao - Advanced Materials, 2023 - Wiley Online Library
Metal–organic frameworks (MOFs) have been at the forefront of nanotechnological research
for the past decade owing to their high porosity, high surface area, diverse configurations …

Ultrasmall alloy nanozyme for ultrasound-and near-infrared light-promoted tumor ablation

D Jana, D Wang, AK Bindra, Y Guo, J Liu, Y Zhao - ACS nano, 2021 - ACS Publications
The therapeutic effect of chemodynamic therapy (CDT) is significantly restricted by the stern
reaction conditions and slow reaction rate of the Fenton reaction (pH 3–4). Herein, we report …

Dual active centers linked by a reversible electron station as a multifunctional nanozyme to induce synergetically enhanced cascade catalysis for tumor-specific …

Q Zhao, L Zheng, Y Gao, J Li, J Wei… - Journal of the …, 2023 - ACS Publications
Nanozymes have shown great promise in reactive oxygen species (ROS)-mediated tumor
therapy with mitigated side effects but are normally limited by the complex tumor …

A copper-metal organic framework enhances the photothermal and chemodynamic properties of polydopamine for melanoma therapy

L Liu, H Zhang, L Peng, D Wang, Y Zhang, B Yan… - Acta Biomaterialia, 2023 - Elsevier
The combination of photothermal treatment and chemodynamic therapy has attracted
extensive attention for improving therapeutic effects and compensating the insufficiency of …