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Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy
B Niu, K Liao, Y Zhou, T Wen, G Quan, X Pan, C Wu - Biomaterials, 2021 - Elsevier
Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a
high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) …
high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) …
Engineering nanomedicine for glutathione depletion-augmented cancer therapy
Y **ong, C **ao, Z Li, X Yang - Chemical Society Reviews, 2021 - pubs.rsc.org
Glutathione (GSH), the main redox buffer, has long been recognized as a pivotal modulator
of tumor initiation, progression and metastasis. It is also implicated in the resistance of …
of tumor initiation, progression and metastasis. It is also implicated in the resistance of …
Guiding transition metal‐doped hollow cerium tandem nanozymes with elaborately regulated multi‐enzymatic activities for intensive chemodynamic therapy
S Dong, Y Dong, B Liu, J Liu, S Liu, Z Zhao… - Advanced …, 2022 - Wiley Online Library
Clinical applications of nanozyme‐initiated chemodynamic therapy (NCDT) have been
severely limited by the poor catalytic efficiency of nanozymes, insufficient endogenous …
severely limited by the poor catalytic efficiency of nanozymes, insufficient endogenous …
Glutathione-depleting nanomedicines for synergistic cancer therapy
X Cheng, HD Xu, HH Ran, G Liang, FG Wu - ACS nano, 2021 - ACS Publications
Cancer cells frequently exhibit resistance to various molecular and nanoscale drugs, which
inevitably affects the drugs' therapeutic outcomes. Overexpression of glutathione (GSH) has …
inevitably affects the drugs' therapeutic outcomes. Overexpression of glutathione (GSH) has …
Recent advances on endogenous/exogenous stimuli-triggered nanoplatforms for enhanced chemodynamic therapy
Q Sun, Z Wang, B Liu, F He, S Gai, P Yang… - Coordination Chemistry …, 2022 - Elsevier
In view of certain unique internalization features of the tumor microenvironment
(TME)(mainly including hypoxia, acidity and higher concentrations of H 2 O 2 and GSH) …
(TME)(mainly including hypoxia, acidity and higher concentrations of H 2 O 2 and GSH) …
A Fluorinated BODIPY-Based Zirconium Metal–Organic Framework for In Vivo Enhanced Photodynamic Therapy
Photodynamic therapy (PDT), an emergent noninvasive cancer treatment, is largely
dependent on the presence of efficient photosensitizers (PSs) and a sufficient oxygen …
dependent on the presence of efficient photosensitizers (PSs) and a sufficient oxygen …
Metal–organic frameworks meet polymers: from synthesis strategies to healthcare applications
Metal–organic frameworks (MOFs) have been at the forefront of nanotechnological research
for the past decade owing to their high porosity, high surface area, diverse configurations …
for the past decade owing to their high porosity, high surface area, diverse configurations …
Ultrasmall alloy nanozyme for ultrasound-and near-infrared light-promoted tumor ablation
The therapeutic effect of chemodynamic therapy (CDT) is significantly restricted by the stern
reaction conditions and slow reaction rate of the Fenton reaction (pH 3–4). Herein, we report …
reaction conditions and slow reaction rate of the Fenton reaction (pH 3–4). Herein, we report …
Dual active centers linked by a reversible electron station as a multifunctional nanozyme to induce synergetically enhanced cascade catalysis for tumor-specific …
Q Zhao, L Zheng, Y Gao, J Li, J Wei… - Journal of the …, 2023 - ACS Publications
Nanozymes have shown great promise in reactive oxygen species (ROS)-mediated tumor
therapy with mitigated side effects but are normally limited by the complex tumor …
therapy with mitigated side effects but are normally limited by the complex tumor …
A copper-metal organic framework enhances the photothermal and chemodynamic properties of polydopamine for melanoma therapy
L Liu, H Zhang, L Peng, D Wang, Y Zhang, B Yan… - Acta Biomaterialia, 2023 - Elsevier
The combination of photothermal treatment and chemodynamic therapy has attracted
extensive attention for improving therapeutic effects and compensating the insufficiency of …
extensive attention for improving therapeutic effects and compensating the insufficiency of …