ACG clinical guideline: genetic testing and management of hereditary gastrointestinal cancer syndromes
S Syngal, RE Brand, JM Church… - Official journal of the …, 2015 - journals.lww.com
This guideline presents recommendations for the management of patients with hereditary
gastrointestinal cancer syndromes. The initial assessment is the collection of a family history …
gastrointestinal cancer syndromes. The initial assessment is the collection of a family history …
Hereditary and familial colon cancer
KW Jasperson, TM Tuohy, DW Neklason, RW Burt - Gastroenterology, 2010 - Elsevier
Between 2% to 5% of all colon cancers arise in the setting of well-defined inherited
syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated …
syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated …
Microsatellite instability is associated with the presence of Lynch syndrome pan-cancer
PURPOSE Microsatellite instability (MSI) and/or mismatch repair deficiency (MMR-D) testing
has traditionally been performed in patients with colorectal (CRC) and endometrial cancer …
has traditionally been performed in patients with colorectal (CRC) and endometrial cancer …
Milestones of Lynch syndrome: 1895–2015
HT Lynch, CL Snyder, TG Shaw, CD Heinen… - Nature Reviews …, 2015 - nature.com
Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer
condition, is characterized by the predisposition to a spectrum of cancers, primarily …
condition, is characterized by the predisposition to a spectrum of cancers, primarily …
Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database
Purpose Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch
syndrome and result in different but imprecisely known cancer risks. This study aimed to …
syndrome and result in different but imprecisely known cancer risks. This study aimed to …
Prevalence and penetrance of major genes and polygenes for colorectal cancer
Background: Although high-risk mutations in identified major susceptibility genes (DNA
mismatch repair genes and MUTYH) account for some familial aggregation of colorectal …
mismatch repair genes and MUTYH) account for some familial aggregation of colorectal …
Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on colorectal cancer
FM Giardiello, JI Allen, JE Axilbund, CR Boland… - Gastroenterology, 2014 - Elsevier
The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to
assist health care providers with the appropriate provision of genetic testing and …
assist health care providers with the appropriate provision of genetic testing and …
Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications
HT Lynch, PM Lynch, SJ Lanspa, CL Snyder… - Clinical …, 2009 - Wiley Online Library
More than one million patients will manifest colorectal cancer (CRC) this year of which,
conservatively, approximately 3%(∼ 30,700 cases) will have Lynch syndrome (LS), the most …
conservatively, approximately 3%(∼ 30,700 cases) will have Lynch syndrome (LS), the most …
Population genetic screening efficiently identifies carriers of autosomal dominant diseases
Three inherited autosomal dominant conditions—BRCA-related hereditary breast and
ovarian cancer (HBOC), Lynch syndrome (LS) and familial hypercholesterolemia (FH) …
ovarian cancer (HBOC), Lynch syndrome (LS) and familial hypercholesterolemia (FH) …
[HTML][HTML] A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for …
Disclaimer: The practice guidelines of the American College of Medical Genetics and
Genomics (ACMG) and the National Society of Genetic Counselors (NSGC) are developed …
Genomics (ACMG) and the National Society of Genetic Counselors (NSGC) are developed …