Dirofilariasis represents a zoonotic mosaic, which includes two main filarial species
(Dirofilaria immitis and D. repens) that have adapted to canine, feline, and human hosts with …

Heartworm disease due to Dirofilaria immitis continues to cause severe disease and even
death in dogs and other animals in many parts of the world, even though safe, highly …

Conventional oral therapy of lymphatic filariasis drugs is only effective to kill microfilariae in
the bloodstream, but is often ineffective to kill adult filarial (macrofilariae) in the complex …

Since the 1950s, medical communities have been facing with emerging and reemerging
infectious diseases, and emerging pathogens are now considered to be a major …

Complete genome DNA sequence and analysis is presented for Wolbachia, the obligate
alpha-proteobacterial endosymbiont required for fertility and survival of the human filarial …

Filarial nematodes are important helminth parasites of the tropics and a leading cause of
global disability. They include species responsible for onchocerciasis, lymphatic filariasis …

Monocyte-derived dendritic cells (DCs) and macrophages (Mϕs) generated in vitro from the
same individual blood donors were exposed to 5 different pathogens, and gene expression …

Parasitic helminths, or worms, comprise a diverse group of metazoan organisms that infect
billions of people and their domesticated animals worldwide (22). In large part …

Lymphatic filariasis is a disease of considerable socioeconomic burden in the tropics.
Presently used antifilarial drugs are able to strongly reduce transmission and will thus …

Among the causes of lymphoedema (LE), secondary LE due to filariasis is the most
prevalent. It affects only a minority of the 120 million people infected with the causative …