The amyloid-β oligomer hypothesis: beginning of the third decade
The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
Copper dyshomeostasis in neurodegenerative diseases—therapeutic implications
G Gromadzka, B Tarnacka, A Flaga… - International journal of …, 2020 - mdpi.com
Copper is one of the most abundant basic transition metals in the human body. It takes part
in oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining the integrity …
in oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining the integrity …
Current research therapeutic strategies for Alzheimer's disease treatment
Alzheimer's disease (AD) currently presents one of the biggest healthcare issues in the
developed countries. There is no effective treatment capable of slowing down disease …
developed countries. There is no effective treatment capable of slowing down disease …
[HTML][HTML] Visualizing and trap** transient oligomers in amyloid assembly pathways
Oligomers which form during amyloid fibril assembly are considered to be key contributors
towards amyloid disease. However, understanding how such intermediates form, their …
towards amyloid disease. However, understanding how such intermediates form, their …
8-Hydroxyquinolines in medicinal chemistry: A structural perspective
V Oliveri, G Vecchio - European journal of medicinal chemistry, 2016 - Elsevier
Hydroxyquinolines are heterocyclic compounds characterized by a moderate metal-binding
affinity. The interest in 8-hydroxyquinolines has grown exponentially in the last two decades …
affinity. The interest in 8-hydroxyquinolines has grown exponentially in the last two decades …
Copper toxicity links to pathogenesis of Alzheimer's disease and therapeutics approaches
HW Ejaz, W Wang, M Lang - International Journal of Molecular Sciences, 2020 - mdpi.com
Alzheimer's disease (AD) is an irreversible, age-related progressive neurological disorder,
and the most common type of dementia in aged people. Neuropathological lesions of AD …
and the most common type of dementia in aged people. Neuropathological lesions of AD …
Biomedical applications of copper ionophores
V Oliveri - Coordination Chemistry Reviews, 2020 - Elsevier
Copper dyshomeostasis is associated with a plethora of diseases, supporting the possibility
of applying copper ionophores to regenerate the metal homeostasis and treat copper …
of applying copper ionophores to regenerate the metal homeostasis and treat copper …
Theories of aging and the prevalence of Alzheimer's disease
K Trevisan, R Cristina-Pereira… - BioMed research …, 2019 - Wiley Online Library
Objective. Aging and AD are associated in some way, then it is reasonable to ask whether or
not it is possible to age without AD inexorably appearing at any moment, depending on the …
not it is possible to age without AD inexorably appearing at any moment, depending on the …
Role of metal cations of copper, Iron, and aluminum and multifunctional ligands in Alzheimer's disease: Experimental and computational insights
Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people
around the world. Even though the causes of AD are not completely understood due to its …
around the world. Even though the causes of AD are not completely understood due to its …
High-resolution probing of early events in amyloid-β aggregation related to Alzheimer's disease
In Alzheimer's disease (AD), soluble oligomers of amyloid-β (Aβ) are emerging as a crucial
entity in driving disease progression as compared to insoluble amyloid deposits. The lacuna …
entity in driving disease progression as compared to insoluble amyloid deposits. The lacuna …