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[HTML][HTML] The role of cysteine protease cathepsins B, H, C, and X/Z in neurodegenerative diseases and cancer
Papain-like cysteine proteases are composed of 11 human cysteine cathepsins, originally
located in the lysosomes. They exhibit broad specificity and act as endopeptidases and/or …
located in the lysosomes. They exhibit broad specificity and act as endopeptidases and/or …
The endo-lysosomal system in Parkinson's disease: Expanding the horizon
Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease, and its prevalence is increasing with age. A wealth of genetic evidence …
Alzheimer's disease, and its prevalence is increasing with age. A wealth of genetic evidence …
A proteogenomic view of Parkinson's disease causality and heterogeneity
The pathogenesis and clinical heterogeneity of Parkinson's disease (PD) have been
evaluated from molecular, pathophysiological, and clinical perspectives. High-throughput …
evaluated from molecular, pathophysiological, and clinical perspectives. High-throughput …
[HTML][HTML] RIT2 regulates autophagy lysosomal pathway induction and protects against α-synuclein pathology in a cellular model of Parkinson's disease
Substantial work has been devoted to better understand the contribution of the myriad of
genes that may underly the development of Parkinson's disease (PD) and their role in …
genes that may underly the development of Parkinson's disease (PD) and their role in …
Cathepsins and Parkinson's disease: insights from Mendelian randomization analyses
A Yusufujiang, S Zeng, H Li - Frontiers in Aging Neuroscience, 2024 - frontiersin.org
Background Parkinson's disease (PD), the second most prevalent neurodegenerative
condition, has a multifaceted etiology. Cathepsin-cysteine proteases situated within …
condition, has a multifaceted etiology. Cathepsin-cysteine proteases situated within …
Systemic inflammation and risk of Parkinson's disease: a prospective cohort study and genetic analysis
C Li, B Ke, J Chen, Y **ao, S Wang, R Jiang… - Brain, behavior, and …, 2024 - Elsevier
Background Multiple evidence has suggested the complex interplay between Parkinson's
disease (PD) and systemic inflammation marked by C-reactive protein (CRP) and interleukin …
disease (PD) and systemic inflammation marked by C-reactive protein (CRP) and interleukin …
Exploring the association between cathepsin B and Parkinson's Disease
Objective: The aim of this study is to investigate the association between Cathepsin B and
Parkinson's Disease (PD), with a particular focus on determining the role of N …
Parkinson's Disease (PD), with a particular focus on determining the role of N …
Cathepsin-mediated regulation of alpha-synuclein in Parkinson's disease: a Mendelian randomization study
L Lin, Z Wu, H Luo, Y Huang - Frontiers in Aging Neuroscience, 2024 - frontiersin.org
Objective The observational association between cathepsin and Parkinson's disease (PD)
has been partially explored in previous research. However, the causal relationship remains …
has been partially explored in previous research. However, the causal relationship remains …
Cathepsins and neurological diseases: a Mendelian randomization study
H Sun, Q Tang, X Yan, W **e, Y Xu… - Frontiers in …, 2024 - frontiersin.org
Background The causal relationship between cathepsins and neurological diseases
remains uncertain. To address this, we utilized a two-sample Mendelian randomization (MR) …
remains uncertain. To address this, we utilized a two-sample Mendelian randomization (MR) …
[HTML][HTML] Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause autosomal dominant
Parkinson's disease (PD), with the most common causative mutation being the LRRK2 p …
Parkinson's disease (PD), with the most common causative mutation being the LRRK2 p …