[HTML][HTML] The role of cysteine protease cathepsins B, H, C, and X/Z in neurodegenerative diseases and cancer

V Stoka, O Vasiljeva, H Nakanishi, V Turk - International journal of …, 2023 - mdpi.com
Papain-like cysteine proteases are composed of 11 human cysteine cathepsins, originally
located in the lysosomes. They exhibit broad specificity and act as endopeptidases and/or …

The endo-lysosomal system in Parkinson's disease: Expanding the horizon

A Muraleedharan, B Vanderperre - Journal of Molecular Biology, 2023 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease, and its prevalence is increasing with age. A wealth of genetic evidence …

A proteogenomic view of Parkinson's disease causality and heterogeneity

S Kaiser, L Zhang, B Mollenhauer, J Jacob… - npj Parkinson's …, 2023 - nature.com
The pathogenesis and clinical heterogeneity of Parkinson's disease (PD) have been
evaluated from molecular, pathophysiological, and clinical perspectives. High-throughput …

[HTML][HTML] RIT2 regulates autophagy lysosomal pathway induction and protects against α-synuclein pathology in a cellular model of Parkinson's disease

AYL Gao, DR Montagna, WD Hirst, PA Temkin - Neurobiology of Disease, 2024 - Elsevier
Substantial work has been devoted to better understand the contribution of the myriad of
genes that may underly the development of Parkinson's disease (PD) and their role in …

Cathepsins and Parkinson's disease: insights from Mendelian randomization analyses

A Yusufujiang, S Zeng, H Li - Frontiers in Aging Neuroscience, 2024 - frontiersin.org
Background Parkinson's disease (PD), the second most prevalent neurodegenerative
condition, has a multifaceted etiology. Cathepsin-cysteine proteases situated within …

Systemic inflammation and risk of Parkinson's disease: a prospective cohort study and genetic analysis

C Li, B Ke, J Chen, Y **ao, S Wang, R Jiang… - Brain, behavior, and …, 2024 - Elsevier
Background Multiple evidence has suggested the complex interplay between Parkinson's
disease (PD) and systemic inflammation marked by C-reactive protein (CRP) and interleukin …

Exploring the association between cathepsin B and Parkinson's Disease

C Lu, X Cai, S Zhi, X Wen, J Shen, T Ercoli, ER Simula… - Brain Sciences, 2024 - mdpi.com
Objective: The aim of this study is to investigate the association between Cathepsin B and
Parkinson's Disease (PD), with a particular focus on determining the role of N …

Cathepsin-mediated regulation of alpha-synuclein in Parkinson's disease: a Mendelian randomization study

L Lin, Z Wu, H Luo, Y Huang - Frontiers in Aging Neuroscience, 2024 - frontiersin.org
Objective The observational association between cathepsin and Parkinson's disease (PD)
has been partially explored in previous research. However, the causal relationship remains …

Cathepsins and neurological diseases: a Mendelian randomization study

H Sun, Q Tang, X Yan, W **e, Y Xu… - Frontiers in …, 2024 - frontiersin.org
Background The causal relationship between cathepsins and neurological diseases
remains uncertain. To address this, we utilized a two-sample Mendelian randomization (MR) …

[HTML][HTML] Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2

I Nazish, A Mamais, A Mallach, C Bettencourt… - Cells, 2023 - mdpi.com
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause autosomal dominant
Parkinson's disease (PD), with the most common causative mutation being the LRRK2 p …