Metabolic dysfunction is a well-established feature of Alzheimer's disease (AD), evidenced
by brain glucose hypometabolism that can be observed potentially decades prior to the …

The past 20 years have resulted in unprecedented progress in understanding brain energy
metabolism and its role in health and disease. In this review, which was initiated at the 14th …

To investigate the dependence of LH pulsatility on energy availability (dietary energy intake
minus exercise energy expenditure), we measured LH pulsatility after manipulating the …

Dietary restriction has been shown to have several health benefits including increased
insulin sensitivity, stress resistance, reduced morbidity, and increased life span. The …

Abstract β-Hydroxybutyrate (βOHB), a ketone body, is oxidised as a brain fuel. Although its
contribution to energy metabolism in the healthy brain is minimal, it is an interesting …

Recent research has revealed potential advantages of feeding an elevated plane of nutrition
to calves during the preweaning period. However, calves fed more nutrients preweaning …

To determine whether plasma lactate can be a significant fuel for human brain energy
metabolism, infusions of [3-13C] lactate and 1H-13C polarization transfer spectroscopy were …

Ketone bodies (KBs) are an important source of energy for the brain. During the neonatal
period, they are also precursors for the synthesis of lipids (especially cholesterol) and amino …

This tutorial provides a comprehensive description of the GC-MS-based untargeted
metabolomics workflow including: ethical approval requirement, sample collection and …

Although the mechanisms underlying the anti-seizure effects of the high-fat ketogenic diet
(KD) remain unclear, a long-standing question has been whether ketone bodies (ie, β …