Although scleroderma is generally considered a fibrosing disease of the tissues, it is now
recognized that the underlying vascular disease is playing a fundamental role in its …

Pulmonary arterial hypertension (PAH) is a severe manifestation of systemic sclerosis (SSc)
and systemic lupus erythematosus (SLE). Due to improvements in the understanding of the …

Objective. Clinical markers are needed to identify scleroderma patients at risk for pulmonary
arterial hypertension (PAH) since early therapy may improve survival. We investigated …

Systemic sclerosis (SSc) is a connective tissue disease of autoimmune origin characterized
by vascular dysfunction and extensive fibrosis of the skin and visceral organs. Vascular …

Systemic sclerosis is a connective tissue disease of unknown origin that is characterized by
immune system abnormalities, vascular damage, and extensive fibrosis of the skin and …

Objective. Cutaneous telangiectases are a characteristic and psychologically distressing
feature of SSc. Our aim was to assess the efficacy of two light-based treatments: pulsed dye …

Vasculopathy is common in patients with connective tissue disease and can be directly
implicated in the pathogenesis of the disease. Systemic sclerosis is an auto-immune …

Background Systemic Sclerosis (SSc) is a rare autoimmune disease whose pathogenesis is
still poorly understood. The Transforming Growth Factor β superfamily is considered pivotal …

Telangiectasia are cardinal features of systemic sclerosis (SS) and calcinosis, Raynaud's
syndrome, esophageal motility, sclerodactyly, telangiectasias (CREST) syndrome. The …

Cutaneous telangiectasia (Tel) are visible permanently dilated postcapillary dermal venules
and are one of the most common disease-specific manifestations of systemic sclerosis …