Chagas disease, leishmaniasis and schistosomiasis are neglected diseases (NDs) and are
a considerable global challenge. Despite the huge number of people infected, NDs do not …

Chagas disease, also known as American trypanosomiasis, is one of the 17 neglected
tropical diseases (NTDs) according to World Health Organization. It is estimated that 8–10 …

The nitro group is considered to be a versatile and unique functional group in medicinal
chemistry. Despite a long history of use in therapeutics, the nitro group has toxicity issues …

The AT-rich mitochondrial DNA (kDNA) of trypanosomatid parasites is a target of DNA minor
groove binders. We report the synthesis, antiprotozoal screening, and SAR studies of three …

Interest in nitroheterocyclic drugs for the treatment of infectious diseases has undergone a
resurgence in recent years. Here we review the current status of monocyclic and bicyclic …

Abstract Chagas disease and Human African trypanosomiasis (HAT) are caused by
Trypanosoma cruzi, T. brucei rhodesiense or T. b. gambiense parasites, respectively; while …

Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal
agents by modification of the stereoelectronic effects of the substituents on N-1 and N-4 and …

The first diaza-[1, 2]-Wittig rearrangement-enabled dearomative spiroannulation (DSA)
reaction of indoles is reported. In contrast to the previous dearomatization approaches using …

The multistep translational science behind new drugs comprehends the entire process
through laboratory, clinical, and community observations turned into health interventions …

Trichomonas vaginalis is a major non-viral sexually-transmitted infection resulted into
serious obstetrical and gynecological troubles. The increasing resistance to nitroimidazole …