Biological functions of fucose in mammals
Fucose is a 6-deoxy hexose in the l-configuration found in a large variety of different
organisms. In mammals, fucose is incorporated into N-glycans, O-glycans and glycolipids by …
organisms. In mammals, fucose is incorporated into N-glycans, O-glycans and glycolipids by …
Emerging structural insights into glycosyltransferase-mediated synthesis of glycans
Glycans linked to proteins and lipids play key roles in biology; thus, accurate replication of
cellular glycans is crucial for maintaining function following cell division. The fact that …
cellular glycans is crucial for maintaining function following cell division. The fact that …
Protein O-fucosylation: structure and function
BC Holdener, RS Haltiwanger - Current opinion in structural biology, 2019 - Elsevier
Highlights•Protein O-fucosyltransferases 1 and 2 (POFUT1 and POFUT2) are ER-localized
and modify EGF repeats and TSRs.•Both POFUT1 and POFUT2 are exquisitely selective for …
and modify EGF repeats and TSRs.•Both POFUT1 and POFUT2 are exquisitely selective for …
Structure and dynamics of the Arabidopsis O-fucosyltransferase SPINDLY
SPINDLY (SPY) in Arabidopsis thaliana is a novel nucleocytoplasmic protein O-
fucosyltransferase (POFUT), which regulates diverse developmental processes. Sequence …
fucosyltransferase (POFUT), which regulates diverse developmental processes. Sequence …
Structural basis for substrate specificity and catalysis of α1, 6-fucosyltransferase
Core-fucosylation is an essential biological modification by which a fucose is transferred
from GDP-β-L-fucose to the innermost N-acetylglucosamine residue of N-linked glycans. A …
from GDP-β-L-fucose to the innermost N-acetylglucosamine residue of N-linked glycans. A …
3D Structure and Function of Glycosyltransferases Involved in N-glycan Maturation
Glycosylation is the most ubiquitous post-translational modification in eukaryotes. N-glycan
is attached to nascent glycoproteins and is processed and matured by various glycosidases …
is attached to nascent glycoproteins and is processed and matured by various glycosidases …
Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3
A Shcherbakova, B Tiemann… - Proceedings of the …, 2017 - National Acad Sciences
Thrombospondin type 1 repeats (TSRs) occur in diverse proteins involved in adhesion and
signaling. The two extracellular TSRs of the netrin receptor UNC5A contain WxxWxxWxxC …
signaling. The two extracellular TSRs of the netrin receptor UNC5A contain WxxWxxWxxC …
SPINDLY O-fucosylates nuclear and cytoplasmic proteins involved in diverse cellular processes in plants
R Zentella, Y Wang, E Zahn, J Hu, L Jiang… - Plant …, 2023 - academic.oup.com
SPINDLY (SPY) is a novel nucleocytoplasmic protein O-fucosyltransferase that regulates
target protein activity or stability via O-fucosylation of specific Ser/Thr residues. Previous …
target protein activity or stability via O-fucosylation of specific Ser/Thr residues. Previous …
The conformational plasticity of glycosyltransferases
D Albesa-Jové, ME Guerin - Current opinion in structural biology, 2016 - Elsevier
Highlights•GTs are highly selective in nature.•Structural snapshots provided insights into the
catalytic mechanisms of GTs.•GTs have evolved a series of mechanisms to gain functionality …
catalytic mechanisms of GTs.•GTs have evolved a series of mechanisms to gain functionality …
Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1
Z Li, K Han, JE Pak, M Satkunarajah, D Zhou… - Nature chemical …, 2017 - nature.com
Abstract Protein O-fucosyltransferase 1 (POFUT1) fucosylates the epidermal growth factor
(EGF)-like domains found in cell-surface and secreted glycoproteins including Notch and its …
(EGF)-like domains found in cell-surface and secreted glycoproteins including Notch and its …