Identification of active compounds in Vernonia anthelmintica (L.) willd by targeted metabolome MRM and kaempferol promotes HaCaT cell proliferation and reduces …

W Hu, H Wang, K Li, Z Lei, F **ang, J Li… - Frontiers in …, 2024‏ - frontiersin.org
Introduction: Vernonia anthelmintica (L.) Willd. is a traditional treatment for vitiligo in
**njiang. However, its therapeutic mechanism remains unclear owing to its complex …

SCAMP3 is a mutant EGFR phosphorylation target and a tumor suppressor in lung adenocarcinoma

A Venugopalan, M Lynberg, CM Cultraro, KDP Nguyen… - Oncogene, 2021‏ - nature.com
Mutations in the epidermal growth factor receptor (EGFR) tyrosine kinase domain
constitutively activate EGFR resulting in lung tumorigenesis. Activated EGFR modulates …

Preparation of a phosphotyrosine-protein standard for use in semiquantitative western blotting with enhanced chemiluminescence

N Kendrick, G Powers, J Johansen, M Hoelter, A Koll… - PLoS …, 2020‏ - journals.plos.org
Protein tyrosine phosphorylation is key to activation of receptor tyrosine kinases (RTK) that
drive development of some cancers. One challenge of RTK-targeted therapy is identification …

Quantitative targeted proteomic analysis of potential markers of tyrosine kinase inhibitor (TKI) sensitivity in EGFR mutated lung adenocarcinoma

S Awasthi, T Maity, BL Oyler, Y Qi, X Zhang… - Journal of …, 2018‏ - Elsevier
Lung cancer causes the highest mortality among all cancers. Patients harboring kinase
domain mutations in the epidermal growth factor receptor (EGFR) respond to EGFR tyrosine …

Regulation of MEK inhibitor selumetinib sensitivity by AKT phosphorylation in the novel BRAF L525R mutant

C Nakai, S Mimaki, K Matsushima, E Shinozaki… - International Journal of …, 2023‏ - Springer
Background Oncogenic mutations in BRAF genes are found in approximately 5–10% of
colorectal cancers. The majority of BRAF mutations are located within exons 11–15 of the …

Analysis of phenylpropanoid components and antioxidant and uric acid-lowering activities of ginger.

J Li, W Jiao, Q **, S Mi, Y Lian, Y Sang, X Wang - 2023‏ - cabidigitallibrary.org
In order to explore the biological functions of active ingredients in dried ginger, high
performance liquid chromatography (HPLC) and mass spectrometry (MS) with selective …