[HTML][HTML] Sunitinib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers
Currently, renal cell carcinoma (RCC) is the most prevalent type of kidney cancer. Targeted
therapy has replaced radiation therapy and chemotherapy as the main treatment option for …
therapy has replaced radiation therapy and chemotherapy as the main treatment option for …
An epigenetic role of mitochondria in cancer
Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …
The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells
Using a mouse model of human MLL-AF9 leukemia, we identified the lysine-specific
demethylase KDM1A (LSD1 or AOF2) as an essential regulator of leukemia stem cell (LSC) …
demethylase KDM1A (LSD1 or AOF2) as an essential regulator of leukemia stem cell (LSC) …
[HTML][HTML] Regulation of stem cell aging by metabolism and epigenetics
Stem cell aging and exhaustion are considered important drivers of organismal aging. Age-
associated declines in stem cell function are characterized by metabolic and epigenetic …
associated declines in stem cell function are characterized by metabolic and epigenetic …
[HTML][HTML] Chemical biology of protein arginine modifications in epigenetic regulation
Post-translational modifications (PTMs) of histone proteins are a hallmark of epigenetic
regulation. They provide a mechanism to modulate chromatin structure and constitute the …
regulation. They provide a mechanism to modulate chromatin structure and constitute the …
A specific LSD1/KDM1A isoform regulates neuronal differentiation through H3K9 demethylation
Summary Lysine-specific demethylase 1 (LSD1) has been reported to repress and activate
transcription by mediating histone H3K4me1/2 and H3K9me1/2 demethylation, respectively …
transcription by mediating histone H3K4me1/2 and H3K9me1/2 demethylation, respectively …
A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth
L Wang, J Chang, D Varghese, M Dellinger… - Nature …, 2013 - nature.com
The pharmacological inhibition of general transcriptional regulators has the potential to
block growth through targeting multiple tumorigenic signalling pathways simultaneously …
block growth through targeting multiple tumorigenic signalling pathways simultaneously …
Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells
The histone demethylase LSD1 (KDM1A) demethylates mono-and di-methylated (Me2)
lysine (K) 4 on histone H3. High LSD1 expression blocks differentiation and confers a poor …
lysine (K) 4 on histone H3. High LSD1 expression blocks differentiation and confers a poor …
Metabolic methanol: molecular pathways and physiological roles
Methanol has been historically considered an exogenous product that leads only to
pathological changes in the human body when consumed. However, in normal, healthy …
pathological changes in the human body when consumed. However, in normal, healthy …
DNA–protein crosslink proteases in genome stability
Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are
common and bulky DNA lesions that interfere with DNA replication, repair, transcription and …
common and bulky DNA lesions that interfere with DNA replication, repair, transcription and …