Abstract Background In December 2019, a novel human-infecting coronavirus, SARS-CoV-
2, had emerged. The WHO has classified the epidemic as a “public health emergency of …

Hepatocellular carcinoma (HCC) is a highly heterogeneous malignancy with high incidence,
recurrence, and metastasis rates. The emergence of immunotherapy has improved the …

Proteolysis targeting chimera (PROTAC) degradation of pathogenic proteins by hijacking of
the ubiquitin-proteasome-system has become a promising strategy in drug design. The …

The hepatitis C virus (HCV) causes both acute and chronic infection and continues to be a
global problem despite advances in antiviral therapeutics. Current treatments fail to prevent …

Virus invasion activates the host's innate immune response, inducing the production of
numerous cytokines and interferons to eliminate pathogens. Except for viral DNA/RNA, viral …

Herpes simplex virus (HSV) keratitis is one of the leading causes of blindness worldwide.
Additionally, up to 90% of the population in some countries is seropositive for HSV. HSV can …

SARS-CoV-2 outbreak has been declared by World Health Organization as a worldwide
pandemic. However, there are many unknowns about the antigen-specific T-cell-mediated …

As evidence has mounted that virus-infected cells, such as cancer cells, negatively regulate
the function of T-cells via immune checkpoints, it has become increasingly clear that viral …

HCV is a hepatotropic RNA virus recognized for its frequent virulence and fatality worldwide.
Despite many vaccine development programs underway, researchers are on a quest for …

Protein translation is a tightly regulated cellular process that is essential for gene expression
and protein synthesis. The deregulation of this process is increasingly recognized as a …