Cell therapy for cartilage repair

CH Hulme, J Perry, HS McCarthy… - Emerging topics in …, 2021 - portlandpress.com
Regenerative medicine, using cells as therapeutic agents for the repair or regeneration of
tissues and organs, offers great hope for the future of medicine. Cell therapy for treating …

Cell‐based therapies have disease‐modifying effects on osteoarthritis in animal models: A systematic review by the ESSKA Orthobiologic Initiative. Part 3: Umbilical …

Y Sourugeon, A Boffa, C Perucca Orfei… - Knee Surgery …, 2024 - Wiley Online Library
Purpose This systematic review aimed to investigate in animal models the presence of
disease‐modifying effects driven by non‐bone marrow‐derived and non‐adipose‐derived …

Mesenchymal stem/stromal cells-derived extracellular vesicles as a potentially more beneficial therapeutic strategy than MSC-based treatment in a mild metabolic …

K Warmink, JL Rios, S Varderidou-Minasian… - Stem cell research & …, 2023 - Springer
Background Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular
vesicles (MSC-EVs) hold promise as a disease modifying treatment in osteoarthritis (OA) …

Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro …

M Hyland, C Mennan, R Davies, E Wilson… - Stem Cell Reviews and …, 2023 - Springer
Autoimmune conditions, such as rheumatoid arthritis, are characterised by a loss of immune
tolerance, whereby the immune cells attack self-antigens causing pain and inflammation …

Umbilical cord mesenchymal stromal cells for cartilage regeneration applications

E Russo, M Caprnda, P Kruzliak… - Stem Cells …, 2022 - Wiley Online Library
Chondropathies are increasing worldwide, but effective treatments are currently lacking.
Mesenchymal stromal cell (MSCs) transplantation represents a promising approach to …

Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model

J Perry, C Mennan, P Cool, HS McCarthy… - Cartilage, 2024 - journals.sagepub.com
Objective To determine if mesenchymal stromal cells (MSCs) derived from human umbilical
cords (hUC) could reduce degeneration develo** when injected into the knee of a large …

Comparison of the Efficacy of Human Umbilical Cord-Derived and Bone Marrow Aspirate Concentrate Mesenchymal Stem Cells for Cartilage Repair Defects of the …

K Pałka, B Sadlik, P Kamiński, RJ Bułdak… - Journal of Personalized …, 2024 - mdpi.com
Injuries to the articular cartilage of the human knee joint, commonly resulting from trauma,
inflammation, or age-and activity-related wear and tear, have significant implications …

Role of Umbilical Cord-Derived Mesenchymal Stem Cells and Derivatives for Treating Knee Osteoarthritis and Chondral Defects: A Systematic Review

IH Dilogo, LAP Pontoh, AF Canintika… - Clinics in Sports …, 2024 - sportsmed.theclinics.com
Methods Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines
were used in writing this systematic review. The record has been submitted to the …

[HTML][HTML] Efficacy of serum-free cultured human umbilical cord mesenchymal stem cells in the treatment of knee osteoarthritis in mice

KZ **ao, G Liao, GY Huang… - World Journal of Stem …, 2024 - pmc.ncbi.nlm.nih.gov
BACKGROUND We investigated the efficacy of intra-articular injection of human umbilical
cord mesenchymal stem cells (hUC-MSCs) for the treatment of osteoarthritis (OA) …

Human mesenchymal stromal cells enhance cartilage healing in a murine joint surface injury model

J Perry, AJ Roelofs, C Mennan, HS McCarthy… - Cells, 2021 - mdpi.com
Human umbilical cord (hUC)-or bone marrow (hBM)-derived mesenchymal stromal cells
(MSCs) were evaluated as an allogeneic source of cells for cartilage repair. We aimed to …