Clozapine's critical role in treatment resistant schizophrenia: ensuring both safety and use

G Remington, J Lee, O Agid, H Takeuchi… - Expert opinion on …, 2016‏ - Taylor & Francis
Introduction: Clozapine was first introduced as an antipsychotic in the 1970's but a cluster of
deaths, later linked to the drug's risk of agranulocytosis, led to its withdrawal in most …

Treatment strategies for clozapine-induced hypotension: a systematic review

TD Tanzer, T Brouard, SD Pra… - Therapeutic …, 2022‏ - journals.sagepub.com
Background: Clozapine is the most effective medication for treatment–refractory
schizophrenia but is associated with significant adverse drug effects, including hypotension …

Characterization of admission types in medically hospitalized patients prescribed clozapine

JG Leung, ME Hasassri, JN Barreto, S Nelson… - Psychosomatics, 2017‏ - Elsevier
Background Clozapine is the antipsychotic of choice for treatment-resistant schizophrenia;
however, rigorous monitoring is required to prevent or detect adverse drug events that …

[PDF][PDF] Treatment-resistant schizophrenia: challenges and implications for clinical practice

M Šagud - Psychiatria Danubina, 2015‏ - hrcak.srce.hr
TREATMENT-RESISTANT SCHIZOPHRENIA: CHALLENGES AND IMPLICATIONS FOR
CLINICAL PRACTICE Page 1 319 Psychiatria Danubina, 2015; Vol. 27, No. 3, pp 319-326 …

[PDF][PDF] Clozapine-induced constipation: a case report and review of current management guidelines

RS Patel, N Veluri, A Suchorab, K Shah, G Verma - Cureus, 2021‏ - cureus.com
Clozapine is a second-generation antipsychotic recommended after the failure of two or
more antipsychotics for treatment-resistant schizophrenia. Clozapine proved to also …

The novel antipsychotic drug cariprazine and cognition enhancing drugs: indications for their use as the add-on therapy in schizophrenia

FM Werner, R Coveñas - Current Pharmaceutical Design, 2021‏ - benthamdirect.com
Background: Schizophrenia and schizoaffective disorder are treated with antipsychotic
drugs. Some patients show treatment-resistant forms of psychotic disorders, and in this case …

Refractory schizophrenia: quality of life and associated factors

PHB Freitas, JAF Pinto, FDD Nunes… - Acta Paulista de …, 2016‏ - SciELO Brasil
Methods: A cross-sectional study, conducted in the extended western region of Minas
Gerais, which included patients with refractory schizophrenia using the antipsychotic …

[PDF][PDF] Rediscovering clozapine: adverse effects develop—what should you do now

BM Newman, WJ Newman - Current Psychiatry, 2016‏ - cdn.mdedge.com
Severe neutropenia, defined as absolute neutrophil count (ANC)< 500/µL, is a well-known
adverse effect of clozapine that requires specific clinical monitoring, a requirement that was …

[HTML][HTML] Esquizofrenia refratária: qualidade de vida e fatores associados

PHB Freitas, JAF Pinto, FDD Nunes… - Acta Paulista de …, 2016‏ - SciELO Brasil
Objetivo Analisar a qualidade de vida de pessoas com esquizofrenia refratária em uso de
clozapina e seus fatores associados. Métodos Estudo de delineamento transversal …

Morphometry of cortical neurons in acute clozapine and ethanol poisoning

AR Bashirova, DV Sundukov, AS Babkina… - General …, 2020‏ - reanimatology.com
The aim of the study is to summarize the histology and morphometry of cortical neurons in
acute clozapine and ethanol poisoning. Material and methods. Histological examination of …