Cysteine proteases play numerous indispensable roles in the biology of parasitic organisms.
Aside from previously known general catabolic functions and protein processing, cysteine …

Infection of humans with the nematode worm parasite Anisakis simplex was first described in
the 1960s in association with the consumption of raw or undercooked fish. During the 1990s …

Proteases can be categorized based on their substrate specificities or mechanisms of
catalysis. Enzymes cleaving within a polypeptide chain are named endopeptidases, and …

Allicin (thio-2-propene-1-sulfinic acid S-allyl ester) is the main biologically active component
of garlic clove extracts. Its biological activity was attributed to either antioxidant activity or …

An alignment/phylogeny of the papain superfamily of cysteine proteases was created using
an initial structure-based alignment followed by successive iterations of sequence alignment …

Streptococcal pyrogenic exotoxin B (SPE B), a conserved extracellular cysteine protease
expressed by the human pathogenic bacterium Streptococcus pyogenes, was purified and …

Parasites are designed by evolution to invade the host and survive in its organism until they
are ready to reproduce. Parasites release a variety of molecules that help them to penetrate …

The immune response is characterized by its high degree of specificity. B lymphocytes
capable of producing antibodies that react with an antigen are selected to proliferate and to …

The complete sequence of the gene encoding the major cysteine protease from
Trypanosoma cruzi is reported. The amino acid sequence predicted from the gene …

The lack of an experimentally determined structure of a target protein frequently limits the
application of structure-based drug design methods. In an effort to overcome this limitation …