The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was
identified in the late 1980s in the context of research into the type I interferon system …

Orchestrating when and how the cutaneous innate immune system should respond to
commensal or pathogenic microbes is a critical function of the epithelium. The cutaneous …

Successful recovery from lung injury requires the repair and regeneration of alveolar
epithelial cells to restore the integrity of gas-exchanging regions within the lung and …

The normal microflora of the skin includes staphylococcal species that will induce
inflammation when present below the dermis but are tolerated on the epidermal surface …

MicroRNAs are a recently discovered class of posttranscriptional regulators of gene
expression with critical functions in health and disease. Psoriasis is the most prevalent …

A diverse environment challenges skin to maintain temperature, hydration, and electrolyte
balance while also maintaining normal immunological function. Rosacea is a common skin …

The accrual of cytosolic DNA leads to transcription of type I IFNs, proteolytic maturation of
the IL-1 family of cytokines, and pyroptotic cell death. Caspase-1 cleaves pro-IL1β to …

Profound thrombocytopenia occurs in humans with sepsis and in mice administered
lipopolysaccharide (LPS). Growing evidence indicates that platelets may contribute to these …

The epidermal growth factor (EGF) family comprises multiple mediators such as transforming
growth factor-α, amphiregulin, heparin binding-EGF, and epiregulin, which are crucially …

Acne is a common skin disorder of the pilosebaceous unit. In addition to genetic, hormonal
and environmental factors, abnormal colonization by Propionibacterium acnes has been …