A rift that has opened up between basic research (bench) and clinical research and patients
(bed) who need their new treatments, diagnostics and prevention, and this rift is widening …

Chemosensory neurons translate perception of external chemical cues, including odorants,
tastants, and pheromones, into information that drives attraction or avoidance motor …

Both micro-and macroalgae have long been used to augment plant productivity and food
production in various regions of the world through their beneficial effects when applied to …

Parasitic nematodes infect one quarter of the world's population and impact all humans
through widespread infection of crops and livestock. Resistance to current anthelmintics has …

Therapeutic drug development is a long, expensive, and complex process that usually takes
12–15 years. In the early phases of drug discovery, in particular, there is a growing need for …

Caenorhabditis elegans has been proven to be a useful model organism for investigating
molecular and cellular aspects of numerous human diseases. More recently, investigators …

KCNQs are voltage-gated K+ channels that control neuronal excitability and are mutated in
epilepsy and autism spectrum disorder (ASD). KCNQs have been extensively studied in …

Current high‐throughput screening methods for drug discovery rely on the existence of
targets. Moreover, most of the hits generated during screenings turn out to be invalid after …

Axons of adult Caenorhabditis elegans neurons undergo robust regenerative growth after
laser axotomy. Here we show that axotomy of PLM sensory neurons triggers axonal calcium …

Paeoniflorin is the major active compound of total glycoside of paeony in Paeonia lactiflora
Pall. Although several aspects of beneficial effects of paeoniflorin have been described …