Since the early days of foundational studies of nucleic acids, many chemical moieties have
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …

The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …

Summary N6-methyladenosine (m 6 A) is a crucial RNA modification that regulates diverse
biological processes in human cells, but its co-transcriptional deposition and functions …

Abstract N6-methyladenosine (m 6 A) RNA methylation is the most abundant form of mRNA
modification in eukaryotes and is at the front line of biological and biomedical research. This …

RNA methylation is a critical mechanism for regulating the transcription and translation of
specific sequences or for eliminating unnecessary sequences during RNA maturation …

Abstract N6-methyladenosine (m6A) modification, as one of the most common types of inner
RNA modification in eukaryotes, plays a multifunctional role in normal and abnormal …

Abstract N6-methyladenosine (m6A) is an abundant, dynamic mRNA modification that
regulates key steps of cellular mRNA metabolism. m6A in the mRNA coding regions inhibits …

Long noncoding RNAs (lncRNA) regulate a number of aspects of cancer biology. Recent
research has shown that lncRNAs can encode micropeptides that mediate their functions in …

The methyltransferase complex (MTC) deposits N 6-adenosine (m6A) onto RNA, whereas
the microprocessor produces microRNA. Whether and how these two distinct complexes …

Methylation of RNA nucleotides represents an important layer of gene expression
regulation, and perturbation of the RNA methylome is associated with pathophysiology. In …