Excessive sugar consumption is increasingly considered as a contributor to the emerging
epidemics of obesity and the associated cardiometabolic disease. Sugar is added to the diet …

The consumption of fructose as sugar and high-fructose corn syrup has markedly increased
during the past several decades. This trend coincides with the exponential rise of metabolic …

Glucose and fructose are closely related simple sugars, but fructose has been associated
more closely with metabolic disease. Until the 1960s, the major dietary source of fructose …

Consumption of fructose, the sweetest of all naturally occurring carbohydrates, has
increased dramatically in the last 40 years and is today commonly used commercially in soft …

Chronic diseases represent a major challenge in world health. Metabolic syndrome is a
constellation of disturbances affecting several organs, and it has been proposed to be a liver …

Nonalcoholic fatty liver disease (NAFLD) is a new challenge in modern medicine, due to its
high prevalence in the world. The pathogenesis of NAFLD is a complex dysmetabolic …

Excessive sugar consumption and defective glucose sensing by hepatocytes contribute to
the development of metabolic diseases including type 2 diabetes mellitus (T2DM) and …

Absorption of monosaccharides is mainly mediated by Na+-d-glucose cotransporter SGLT1
and the facititative transporters GLUT2 and GLUT5. SGLT1 and GLUT2 are relevant for …

Lipogenesis in liver is highest in the postprandial state; insulin activates SREBP-1c, which
transcriptionally activates genes involved in FA synthesis, whereas glucose activates …

Carbohydrate response element binding protein (ChREBP) is a carbohydrate-signaling
transcription factor that in the past years has emerged as a central metabolic regulator …