Immunomodulatory biomaterials for tissue repair

R Whitaker, B Hernaez-Estrada, RM Hernandez… - Chemical …, 2021 - ACS Publications
All implanted biomaterials are targets of the host's immune system. While the host
inflammatory response was once considered a detrimental force to be blunted or avoided, in …

Macrophage phenotypes in tissue repair and the foreign body response: Implications for biomaterial-based regenerative medicine strategies

KE Martin, AJ García - Acta biomaterialia, 2021 - Elsevier
Macrophages are a highly heterogeneous and plastic population of cells that are crucial for
tissue repair and regeneration. This has made macrophages a particularly attractive target …

Machine learning‐driven biomaterials evolution

A Suwardi, FK Wang, K Xue, MY Han, P Teo… - Advanced …, 2022 - Wiley Online Library
Biomaterials is an exciting and dynamic field, which uses a collection of diverse materials to
achieve desired biological responses. While there is constant evolution and innovation in …

Dealing with the foreign‐body response to implanted biomaterials: strategies and applications of new materials

D Zhang, Q Chen, C Shi, M Chen, K Ma… - Advanced Functional …, 2021 - Wiley Online Library
Foreign‐body response caused by implanted biomaterials seriously impedes the function of
implants and is a major obstacle to the development of implantable biomaterials and …

Glucose‐responsive antioxidant hydrogel accelerates diabetic wound healing

F Chen, J Qin, P Wu, W Gao… - Advanced Healthcare …, 2023 - Wiley Online Library
Diabetic complications can be ameliorated by inhibiting excessive oxidative stress with
antioxidants. To enhance therapeutic intervention, it is crucial to develop intelligent scaffolds …

[HTML][HTML] Interplay between biomaterials and the immune system: Challenges and opportunities in regenerative medicine

D Salthouse, K Novakovic, CMU Hilkens, AM Ferreira - Acta biomaterialia, 2023 - Elsevier
The use of biomaterials for tissue engineering and regenerative medicine applications has
increased dramatically over recent years. However, the clinical uptake of a wide variety of …

High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Intrinsic immunomodulatory hydrogels for chronic inflammation

Y Qian, J Ding, R Zhao, Y Song, J Yoo… - Chemical Society …, 2025 - pubs.rsc.org
The immune system plays a pivotal role in maintaining physiological homeostasis and
influencing disease processes. Dysregulated immune responses drive chronic inflammation …

Spermidine‐Functionalized Injectable Hydrogel Reduces Inflammation and Enhances Healing of Acute and Diabetic Wounds In Situ

Q Wu, R Yang, W Fan, L Wang, J Zhan… - Advanced …, 2024 - Wiley Online Library
The inflammatory response is a key factor affecting tissue regeneration. Inspired by the
immunomodulatory role of spermidine, an injectable double network hydrogel functionalized …

How can machine learning and multiscale modeling benefit ocular drug development?

N Wang, Y Zhang, W Wang, Z Ye, H Chen, G Hu… - Advanced Drug Delivery …, 2023 - Elsevier
The eyes possess sophisticated physiological structures, diverse disease targets, limited
drug delivery space, distinctive barriers, and complicated biomechanical processes …