The NMDA-R hypofunction model of schizophrenia started with the clinical observation of
the precipitation of psychotic symptoms in patients with schizophrenia exposed to PCP or …

Impairment of insulin action and metabolic dysregulation have traditionally been associated
with schizophrenia, although the molecular basis of such association remains still elusive …

Glutamatergic and GABAergic dysfunction are implicated in the pathophysiology of
schizophrenia. Previous work has shown relationships between glutamate, GABA, and brain …

Schizophrenia has been conceptualized as a neurodevelopmental disorder with synaptic
alterations and aberrant cortical–subcortical connections. Antipsychotics are the mainstay of …

Schizophrenia is regarded as a neurodevelopmental disorder with its course progressing
throughout life. However, the aetiology and development of schizophrenia are still under …

Background The immune-inflammatory response system (IRS) and kynurenine pathway
(KP) have been implicated in the pathophysiology of schizophrenia. Studies have shown …

Despite its enduring relevance as the single most effective and important evidence-based
treatment for schizophrenia, underutilization of clozapine remains considerable. To a …

Conceptually, a wide beneficial effect, both peripherally and centrally, might have been
essential for the harmony of brain–gut and gut–brain axes' function. Seen from the original …

Abstract Background and Purpose Clozapine is an effective antipsychotic for treatment‐
resistant schizophrenia, but its discontinuation leads to discontinuation syndrome/catatonia …

Abstract Background and Hypothesis Schizophrenia is a multidimensional disease. This
study proposes a new research framework that combines multimodal meta-analysis and …