Rheumatoid arthritis (RA) is a chronic immune-mediated disease that primarily affects the
synovium of diarthrodial joints. During the course of RA, the synovium transforms into a …

Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of
evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an …

Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

Despite nearly three decades of advances in the management of rheumatoid arthritis (RA), a
substantial minority of patients are exposed to multiple DMARDs without necessarily …

Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which
mediates destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS) are a key …

Toll-like receptor (TLR) signalling must be tightly regulated to avoid excessive inflammation
and to allow for tissue repair and the return to homeostasis after infection and tissue injury …

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial tissue
inflammation and joint destruction associated with the activation of angiogenesis …

Over the last decade, many epigenetic mechanisms that contribute in the pathogenesis of
autoimmune disorders have been revealed. MicroRNAs (miRNAs) are small, non-coding …

Rheumatoid arthritis (RA) is the most common inflammatory arthritis, affecting from 0.5% to
1% of the general population worldwide. Although the prevalence is surprisingly constant …

MicroRNAs (miRNAs) are short non-coding RNAs that act as important regulators of gene
expression as part of the epigenetic machinery. In addition to posttranscriptional gene …