Smart contact lenses as wearable ophthalmic devices for disease monitoring and health management

H Seo, WG Chung, YW Kwon, S Kim, YM Hong… - Chemical …, 2023‏ - ACS Publications
The eye contains a complex network of physiological information and biomarkers for
monitoring disease and managing health, and ocular devices can be used to effectively …

Biological functions of tear film

SC Pflugfelder, ME Stern - Experimental eye research, 2020‏ - Elsevier
Tears have a vital function to protect and lubricate the ocular surface. Tear production,
distribution and clearance is tightly regulated by the lacrimal functional unit (LFU) to meet …

Nano-based eye drop: Topical and noninvasive therapy for ocular diseases

C Wang, Y Pang - Advanced drug delivery reviews, 2023‏ - Elsevier
Eye drops are the most accessible therapy for ocular diseases, while inevitably suffering
from their lower bioavailability which highly restricts the treatment efficacy. The introduction …

Dry eye disease: prevalence, assessment, and management

PA Rouen, ML White - Home healthcare now, 2018‏ - journals.lww.com
Dry eye disease is a chronic condition of the corneal surface marked by persistent symptoms
of irritation or burning that can cause inflammatory damage to the cornea and conjunctiva if …

Lipidomics: techniques, applications, and outcomes related to biomedical sciences

K Yang, X Han - Trends in biochemical sciences, 2016‏ - cell.com
Lipidomics is a newly emerged discipline that studies cellular lipids on a large scale based
on analytical chemistry principles and technological tools, particularly mass spectrometry …

Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine

S Hagan, E Martin, A Enríquez-de-Salamanca - Epma Journal, 2016‏ - Springer
In the field of predictive, preventive and personalised medicine, researchers are keen to
identify novel and reliable ways to predict and diagnose disease, as well as to monitor …

Mass spectrometry analysis of human tear fluid biomarkers specific for ocular and systemic diseases in the context of 3P medicine

X Zhan, J Li, Y Guo, O Golubnitschaja - EPMA Journal, 2021‏ - Springer
Over the last two decades, a large number of non-communicable/chronic disorders reached
an epidemic level on a global scale such as diabetes mellitus type 2, cardio-vascular …

Contact lens sensors in ocular diagnostics

NM Farandos, AK Yetisen, MJ Monteiro… - Advanced …, 2015‏ - Wiley Online Library
Contact lenses as a minimally invasive platform for diagnostics and drug delivery have
emerged in recent years. Contact lens sensors have been developed for analyzing the …

Smart skin‐adhesive patches: from design to biomedical applications

SHD Wong, GR Deen, JS Bates, C Maiti… - Advanced Functional …, 2023‏ - Wiley Online Library
With the advancement of medical and digital technologies, smart skin adhesive patches
have emerged as a key player for complex medical purposes. In particular, skin adhesive …

Biochemistry of human tear film: A review

S Masoudi - Experimental eye research, 2022‏ - Elsevier
The precorneal tear film is a complex mixture of proteins, lipids, metabolites, and electrolytes
with different structures and functionalities. Sustainable production of each tear component …