Cardiac glycosides have played a prominent role in the therapy of congestive heart failure
since William Withering codified their use in his late 18th century monograph on the efficacy …

Digitalis is the oldest compound in cardiovascular medicine that continues to be used in
contemporary clinical practice. 1 Evidence supporting the beneficial effects of digoxin on …

Background The role of cardiac glycosides in treating patients with chronic heart failure and
normal sinus rhythm remains controversial. We studied the effect of digoxin on mortality and …

Background In the general population, obesity is associated with increased risk of adverse
outcomes. However, studies of patients with chronic disease suggest that overweight and …

Objectives: The aim of this study was to assess the prognostic importance of left ventricular
ejection fraction (LVEF) in stable outpatients with heart failure (HF). Background: Although …

Context The Digitalis Investigation Group (DIG) trial reported that digoxin provided no overall
mortality benefit and only a modest reduction in hospitalizations among patients with heart …

Background—About half of the 5 million heart failure patients in the United States have
diastolic heart failure (clinical heart failure with normal or near-normal ejection fraction) …

OBJECTIVES This study was designed to determine the effect of increasing age on mortality,
hospitalizations and digoxin side effects in patients with heart failure (HF), and to determine …

Aims Potassium homeostasis is essential for normal myocardial function, and low serum
potassium may cause fatal arrhythmias. However, the association of low potassium and long …

Abstract Aims The Digitalis Investigation Group (DIG) trial, the only large randomized trial of
digoxin in heart failure, reported a neutral effect on mortality and a significant reduction in …