The majority of the brain's vasculature is composed of intricate capillary networks lined by
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …

The meninges, comprising the leptomeninges (pia and arachnoid layers) and the
pachymeninx (dura layer), participate in central nervous system (CNS) autoimmunity, but …

Capillary networks are essential for distribution of blood flow through the brain, and
numerous other homeostatic functions, including neurovascular signal conduction and …

Neurovascular coupling links brain activity to local changes in blood flow, forming the basis
for non-invasive brain map**. Using multiscale imaging, we investigated how vascular …

Microglia are important players in surveillance and repair of the brain. Implanting an
electrode into the cortex activates microglia, produces an inflammatory cascade, triggers the …

Perivascular fibroblasts (PVFs) are recognized for their pro-fibrotic role in many central
nervous system disorders. Like mural cells, PVFs surround blood vessels and express …

The cerebrovasculature and its mural cells must meet brain regional energy demands, but
how their spatial relationship with different neuronal cell types varies across the brain …

Different segments of the cerebral vascular network may react distinctly to brain ischemia
and recanalization. However, there are limited systematic observations of these vascular …

Biofabrication approaches toward the development of tissue-engineered vascular grafts
(TEVGs) have been widely investigated. However, successful translation has been limited to …

During early ischemic brain injury, glutamate receptor hyperactivation mediates neuronal
death via osmotic cell swelling. Here we show that ischemia and excess NMDA receptor …