The mechanobiology of endothelial-to-mesenchymal transition in cardiovascular disease

S Islam, KI Boström, D Di Carlo, CA Simmons… - Frontiers in …, 2021 - frontiersin.org
Endothelial cells (ECs) lining the cardiovascular system are subjected to a highly dynamic
microenvironment resulting from pulsatile pressure and circulating blood flow. Endothelial …

Prognostic value of mitral regurgitation in patients undergoing left ventricular assist device deployment: A systematic review and meta‐analysis

A Arjomandi Rad, A Zubarevich, V Shah… - Artificial …, 2023 - Wiley Online Library
Background Left ventricular assist devices (LVADs) represent an important therapeutic
option for patients progressing to end‐stage heart failure. LVAD has previously been shown …

FEBio FINESSE: An open-source finite element simulation approach to estimate in vivo heart valve strains using shape enforcement

DW Laurence, PM Sabin, AM Sulentic… - Annals of Biomedical …, 2024 - Springer
Purpose Finite element simulations are an enticing tool to evaluate heart valve function;
however, patient-specific simulations derived from 3D echocardiography are hampered by …

Bayesian optimization-based inverse finite element analysis for atrioventricular heart valves

CJ Ross, DW Laurence, A Aggarwal, MC Hsu… - Annals of Biomedical …, 2024 - Springer
Inverse finite element analysis (iFEA) of the atrioventricular heart valves (AHVs) can provide
insights into the in-vivo valvular function, such as in-vivo tissue strains; however, there are …

Pre-surgical Prediction of Ischemic Mitral Regurgitation Recurrence Using In Vivo Mitral Valve Leaflet Strains

H Narang, BV Rego, AH Khalighi, A Aly… - Annals of biomedical …, 2021 - Springer
Ischemic mitral regurgitation (IMR) is a prevalent cardiac disease associated with substantial
morbidity and mortality. Contemporary surgical treatments continue to have limited long-term …

A computational pipeline for patient-specific prediction of the postoperative mitral valve functional state

H Liu, NT Simonian, AM Pouch… - Journal of …, 2023 - asmedigitalcollection.asme.org
While mitral valve (MV) repair remains the preferred clinical option for mitral regurgitation
(MR) treatment, long-term outcomes remain suboptimal and difficult to predict. Furthermore …

Patient-specific quantitative in-vivo assessment of human mitral valve leaflet strain before and after mitraclip repair

NT Simonian, H Liu, S Vakamudi, MJ Pirwitz… - Cardiovascular …, 2023 - Springer
Purpose Mitral regurgitation (MR) is a highly prevalent and deadly cardiac disease
characterized by improper mitral valve (MV) leaflet coaptation. Among the plethora of …

In vivo assessment of mitral valve leaflet remodelling following myocardial infarction

BV Rego, AH Khalighi, EK Lai, RC Gorman… - Scientific reports, 2022 - nature.com
Abstract Each year, more than 40,000 people undergo mitral valve (MV) repair surgery
domestically to treat regurgitation caused by myocardial infarction (MI). Although continual …

Simulation of mitral valve plasticity in response to myocardial infarction

BV Rego, AH Khalighi, JH Gorman III… - Annals of Biomedical …, 2023 - Springer
Left ventricular myocardial infarction (MI) has broad and debilitating effects on cardiac
function. In many cases, MI leads to ischemic mitral regurgitation (IMR), a condition …

[HTML][HTML] Quantitative in vivo assessment of human mitral valve coaptation area after undersized ring annuloplasty repair for ischemic mitral regurgitation

NT Simonian, H Liu, AM Pouch, JH Gorman III… - Jtcvs Techniques, 2022 - Elsevier
Objectives Long-term outcomes of mitral valve repair procedures to correct ischemic mitral
regurgitation remain unpredictable, due to an incomplete understanding of the disease …