Background A proposed mechanism of chronic pain is dysregulation between the main
inhibitory (GABA) and excitatory (glutamate) neurometabolites of the central nervous system …

Functional magnetic resonance spectroscopy (fMRS) can be used to investigate
neurometabolic responses to external stimuli in-vivo, but findings are inconsistent. We …

Healthy aging is accompanied by motor inhibition deficits that involve a slower process of
stop** a prepotent motor response (ie, reactive inhibition) rather than a diminished ability …

γ-Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the human brain
and can be measured with magnetic resonance spectroscopy (MRS). Conflicting accounts …

Behavioural disinhibition is a common feature of the syndromes associated with
frontotemporal lobar degeneration (FTLD). It is associated with high morbidity and lacks …

Individuals on the autism spectrum are often reported as being hyper-and/or hyporeactive to
sensory input. These sensory symptoms were one of the key observations that led to the …

Accurate and reliable quantification of brain metabolites measured in vivo using 1 H
magnetic resonance spectroscopy (MRS) is a topic of continued interest. Aside from …

Background Adults over age 65 represent the fastest growing population in the US. Decline
in cognitive abilities is a hallmark of advanced age and is associated with loss of …

Abstract Models of healthy brain function and psychiatric conditions assume that excitatory
and inhibitory activity are balanced in the human brain at multiple spatial and temporal …

Purpose The neurometabolic timecourse of healthy aging is not well-established, in part due
to diversity of quantification methodology. In this study, a large structured cross-sectional …