Covering: up to the end of 2021 [2+ 2]-Type cyclobutane natural products are
biosynthetically derived from intermolecular [2+ 2] cycloaddition or intramolecular [2+ 2] …

Complex natural products bearing strained cyclobutane subunits, including terpenoids,
alkaloids and steroids, not only display fascinating architectures, but also show potent …

The release of the inherent ring strain of cyclobutane and cyclopropane derivatives allows a
rapid build-up of molecular complexity. This review highlights the state-of-the-art of the ring …

Here we report a contractive synthesis of multisubstituted cyclobutanes containing multiple
stereocenters from readily accessible pyrrolidines using iodonitrene chemistry. Mediated by …

Nitrogen heterocycles are essential parts of the chemical machinery of life and often reveal
intriguing structures. They are not only widespread in terrestrial habitats but can also …

Abstract An efficient catalytic asymmetric [2+ 2] cycloaddition of allenyl imide and mono‐or
disubstituted alkenes is disclosed. The key feature of this method is the use of bidentate …

Four‐membered carbocycles are important structural motifs found in several natural
products and drugs. Amongst those, cyclobutenes are attractive intermediates because the …

Four-membered carbocycles are fundamental substructures in bioactive molecules and
approved drugs and serve as irreplaceable building blocks in organic synthesis. However …

In spite of the prevalence of fused cyclobutane skeletons in natural products and
pharmaceuticals, synthetic strategies for their assembly from simple starting materials still …

Comprehensive Summary Cyclobutane derivatives have been recognized as useful
structural motifs in organic synthesis and drug design. With the revival of photochemistry, the …