Chemical design and synthesis of functionalized probes for imaging and treating tumor hypoxia

J Liu, W Bu, J Shi - Chemical reviews, 2017‏ - ACS Publications
Hypoxia development in tumor is closely associated with its increased aggressiveness and
strong resistance to therapy, leading to the poor prognosis in several cancer types …

Hyperpolarized 129Xe MRI of the human lung

JP Mugler III, TA Altes - Journal of Magnetic Resonance …, 2013‏ - Wiley Online Library
By permitting direct visualization of the airspaces of the lung, magnetic resonance imaging
(MRI) using hyperpolarized gases provides unique strategies for evaluating pulmonary …

Protocols for multi‐site trials using hyperpolarized 129Xe MRI for imaging of ventilation, alveolar‐airspace size, and gas exchange: A position paper from the 129Xe …

PJ Niedbalski, CS Hall, M Castro… - Magnetic resonance …, 2021‏ - Wiley Online Library
Hyperpolarized (HP) 129Xe MRI uniquely images pulmonary ventilation, gas exchange, and
terminal airway morphology rapidly and safely, providing novel information not possible …

Genetically encoded reporters for hyperpolarized xenon magnetic resonance imaging

MG Shapiro, RM Ramirez, LJ Sperling, G Sun, J Sun… - Nature …, 2014‏ - nature.com
Magnetic resonance imaging (MRI) enables high-resolution non-invasive observation of the
anatomy and function of intact organisms. However, previous MRI reporters of key biological …

Regional map** of gas uptake by blood and tissue in the human lung using hyperpolarized xenon‐129 MRI

K Qing, K Ruppert, Y Jiang, JF Mata… - Journal of magnetic …, 2014‏ - Wiley Online Library
Purpose To develop a breathhold acquisition for regional map** of ventilation and the
fractions of hyperpolarized xenon‐129 (Xe129) dissolved in tissue (lung parenchyma and …

Hyperpolarized 3He and 129Xe MRI: Differences in asthma before bronchodilation

S Svenningsen, M Kirby, D Starr… - Journal of Magnetic …, 2013‏ - Wiley Online Library
Purpose To compare hyperpolarized helium‐3 (3He) and xenon‐129 (129Xe) MRI in
asthmatics before and after salbutamol inhalation. Materials and Methods Seven asthmatics …

Single‐breath clinical imaging of hyperpolarized 129xe in the airspaces, barrier, and red blood cells using an interleaved 3D radial 1‐point Dixon acquisition

SS Kaushik, SH Robertson… - Magnetic resonance …, 2016‏ - Wiley Online Library
Purpose We sought to develop and test a clinically feasible 1‐point Dixon, three‐
dimensional (3D) radial acquisition strategy to create isotropic 3D MR images of 129Xe in …

Childhood to adulthood: Accounting for age dependence in healthy‐reference distributions in 129Xe gas‐exchange MRI

JW Plummer, MM Willmering… - Magnetic resonance …, 2023‏ - Wiley Online Library
Purpose Xenon‐129 (129Xe) gas‐exchange MRI is a pulmonary‐imaging technique that
provides quantitative metrics for lung structure and function and is often compared to …

Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129

JP Mugler III, TA Altes, IC Ruset, IM Dregely… - Proceedings of the …, 2010‏ - pnas.org
Despite a myriad of technical advances in medical imaging, as well as the growing need to
address the global impact of pulmonary diseases, such as asthma and chronic obstructive …

Quantitative analysis of hyperpolarized 129Xe gas transfer MRI

Z Wang, SH Robertson, J Wang, M He… - Medical …, 2017‏ - Wiley Online Library
Purpose Hyperpolarized 129Xe magnetic resonance imaging (MRI) using Dixon‐based
decomposition enables single‐breath imaging of 129Xe in the airspaces, interstitial barrier …