Highlights•Synthetic biomolecular feedback controllers have promising applications in
various fields.•Negative-feedback controllers enhance dynamic performance and reduce …

Abstract Proportional-Integral-Derivative (PID) feedback controllers are the most widely used
controllers in industry. Recently, the design of molecular PID-controllers has been identified …

Sensitive and minimally invasive medical diagnostics are essential to the early detection of
diseases, monitoring their progression and response to treatment. Engineered bacteria as …

Effective and robust regulation of biomolecular processes is crucial for designing reliable
synthetic bio-devices functioning in uncertain and constantly changing biological …

Recently, there has been an increasing need for tools to simulate cell size regulation due to
important applications in cell proliferation and gene expression. However, implementing the …

A key goal of synthetic biology is to develop functional biochemical modules with network-
independent properties. Antithetic integral feedback (AIF) is a recently developed control …

The stochastic logistic model is widely used to capture random fluctuations arising from birth-
death processes in ecological populations. We use this model to study the impact of …

This article presents the first implementation of a proportional-integral-derivative (PID)
biomolecular controller within a consortium of different cell populations, aimed at robust …

Temporal gradient estimation is a pervasive phenomenon in natural biological systems and
holds great promise for synthetic counterparts with broad-reaching applications. Here, we …

We consider the problem of transmitting the state value of a dynamical system through a
communication network. The dynamics of the error in state estimation is modeled using a …