Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …
Regulation of adult neurogenesis in mammalian brain
Adult neurogenesis is a multistage process by which neurons are generated and integrated
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …
3-Nitrotyrosine: a versatile oxidative stress biomarker for major neurodegenerative diseases
M Bandookwala, P Sengupta - International Journal of …, 2020 - Taylor & Francis
Reactive oxygen species are generated as a by-product of routine biochemical reactions.
However, dysfunction of the antioxidant system or mutations in gene function may result in …
However, dysfunction of the antioxidant system or mutations in gene function may result in …
Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease
Several neurodegenerative diseases associated with protein misfolding (Alzheimer's and
Parkinson's disease) exhibit oxidative and nitrergic stress following initiation of …
Parkinson's disease) exhibit oxidative and nitrergic stress following initiation of …
Redox stress and metal dys-homeostasis appear as hallmarks of early prion disease pathogenesis in mice
Neurodegenerative diseases are associated with a multitude of dysfunctional cellular
pathways. One major contributory factor is a redox stress challenge during the development …
pathways. One major contributory factor is a redox stress challenge during the development …
M1 muscarinic acetylcholine receptors: A therapeutic strategy for symptomatic and disease-modifying effects in Alzheimer's disease?
M Scarpa, S Hesse, SJ Bradley - Advances in pharmacology, 2020 - Elsevier
The M1 muscarinic acetylcholine receptor (mAChR) plays a crucial role in learning and
memory processes and has long been identified as a promising therapeutic target for the …
memory processes and has long been identified as a promising therapeutic target for the …
Impairment of neuronal mitochondrial quality control in prion-induced neurodegeneration
Mitochondrial dynamics continually maintain cell survival and bioenergetics through
mitochondrial quality control processes (fission, fusion, and mitophagy). Aberrant …
mitochondrial quality control processes (fission, fusion, and mitophagy). Aberrant …
Dysregulation of stress systems and nitric oxide signaling underlies neuronal dysfunction in Alzheimer's disease
Stress is a multimodal response involving the coordination of numerous body systems in
order to maximize the chance of survival. However, long term activation of the stress …
order to maximize the chance of survival. However, long term activation of the stress …
[HTML][HTML] Machine learning for metabolomics research in drug discovery
DD Martinelli - Intelligence-Based Medicine, 2023 - Elsevier
In a pharmaceutical context, metabolomics is an underexplored area of research.
Nevertheless, its utility in clinical pathology, biomarker discovery, metabolic subty**, and …
Nevertheless, its utility in clinical pathology, biomarker discovery, metabolic subty**, and …
Loss of prion protein control of glucose metabolism promotes neurodegeneration in model of prion diseases
H Arnould, V Baudouin, A Baudry, LW Ribeiro… - PLoS …, 2021 - journals.plos.org
Corruption of cellular prion protein (PrPC) function (s) at the plasma membrane of neurons is
at the root of prion diseases, such as Creutzfeldt-Jakob disease and its variant in humans …
at the root of prion diseases, such as Creutzfeldt-Jakob disease and its variant in humans …