Engineering macrophages for cancer immunotherapy and drug delivery

Y ** polarization and targeting
Q Zhang, M Sioud - International journal of molecular sciences, 2023 - mdpi.com
The tumor microenvironment (TME) is a critical regulator of tumor growth, progression, and
metastasis. Among the innate immune cells recruited to the tumor site, macrophages are the …

[HTML][HTML] Tumor microenvironment remodeling and tumor therapy based on M2-like tumor associated macrophage-targeting nano-complexes

S Han, W Wang, S Wang, T Yang, G Zhang, D Wang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Background: Among the many immunosuppressive cells in the tumor microenvironment,
tumor-associated-macrophages (TAMs) are well known to contribute to tumor development …

Tumor associated macrophages: origin, recruitment, phenotypic diversity, and targeting

T Hourani, JA Holden, W Li, JC Lenzo… - Frontiers in …, 2021 - frontiersin.org
The tumor microenvironment (TME) is known to have a strong influence on tumorigenesis,
with various components being involved in tumor suppression and tumor growth. A …

Progress on modulating tumor‐associated macrophages with biomaterials

M Sylvestre, CA Crane, SH Pun - Advanced Materials, 2020 - Wiley Online Library
Tumor‐associated macrophages (TAMs) are a complex and heterogeneous population of
cells within the tumor microenvironment. In many tumor types, TAMs contribute toward tumor …

M2 macrophage-derived exosomal microRNA-155-5p promotes the immune escape of colon cancer by downregulating ZC3H12B

YS Ma, TM Wu, CC Ling, F Yu, J Zhang, PS Cao… - Molecular Therapy …, 2021 - cell.com
Previous evidence has highlighted M2 macrophage regulation of cancer cells via exosome
shuttling of microRNAs (miRNAs or miRs). The current study set out to explore the possible …

Design of polymeric carriers for intracellular peptide delivery in oncology applications

S Lv, M Sylvestre, AN Prossnitz, LF Yang… - Chemical …, 2021 - ACS Publications
In recent decades, peptides, which can possess high potency, excellent selectivity, and low
toxicity, have emerged as promising therapeutics for cancer applications. Combined with an …

Current understandings and clinical translation of nanomedicines for breast cancer therapy

Y Jiang, Z Jiang, M Wang, L Ma - Advanced drug delivery reviews, 2022 - Elsevier
Breast cancer is one of the most frequently diagnosed cancers that is threatening women's
life. Current clinical treatment regimens for breast cancer often involve neoadjuvant and …