[HTML][HTML] Western diet consumption during development: setting the stage for neurocognitive dysfunction
The dietary pattern in industrialized countries has changed substantially over the past
century due to technological advances in agriculture, food processing, storage, marketing …
century due to technological advances in agriculture, food processing, storage, marketing …
[HTML][HTML] Reviewing pharmacogenetics to advance precision medicine for opioids
Background Adequate opioid prescribing is critical for therapeutic success of pain
management. Despite the widespread use of opioids, optimized opioid therapy remains …
management. Despite the widespread use of opioids, optimized opioid therapy remains …
Unlocking opioid neuropeptide dynamics with genetically encoded biosensors
Neuropeptides are ubiquitous in the nervous system. Research into neuropeptides has
been limited by a lack of experimental tools that allow for the precise dissection of their …
been limited by a lack of experimental tools that allow for the precise dissection of their …
16p11. 2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro
Reciprocal copy number variations (CNVs) of 16p11. 2 are associated with a wide spectrum
of neuropsychiatric and neurodevelopmental disorders. Here, we use human induced …
of neuropsychiatric and neurodevelopmental disorders. Here, we use human induced …
Dopamine‐conjugated extracellular vesicles induce autophagy in Parkinson's disease
The application of extracellular vesicles (EVs) as vehicles for anti‐Parkinson's agents
represents a significant advance, yet their clinical translation is hampered by challenges in …
represents a significant advance, yet their clinical translation is hampered by challenges in …
Proposing a “brain health checkup (BHC)” as a global potential “standard of care” to overcome reward dysregulation in primary care medicine: Coupling genetic risk …
ER Braverman, CA Dennen, MS Gold… - International Journal of …, 2022 - mdpi.com
In 2021, over 100,000 people died prematurely from opioid overdoses. Neuropsychiatric
and cognitive impairments are underreported comorbidities of reward dysregulation due to …
and cognitive impairments are underreported comorbidities of reward dysregulation due to …
[HTML][HTML] Placental DNA methylation profiles in opioid-exposed pregnancies and associations with the neonatal opioid withdrawal syndrome
Opioid abuse during pregnancy can result in Neonatal Opioid Withdrawal Syndrome
(NOWS). We investigated genome-wide methylation analyses of 96 placental tissue …
(NOWS). We investigated genome-wide methylation analyses of 96 placental tissue …
Association of the OPRM1 A118G polymorphism and Pavlovian-to-instrumental transfer: Clinical relevance for alcohol dependence
Background: Pavlovian-to-instrumental transfer (PIT) quantifies the extent to which a
stimulus that has been associated with reward or punishment alters operant behaviour. In …
stimulus that has been associated with reward or punishment alters operant behaviour. In …
Endogenous opiates and behavior: 2019
RJ Bodnar - Peptides, 2021 - Elsevier
This paper is the forty-second consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …
research concerning the endogenous opioid system, summarizing articles published during …
Proteomic analysis unveils expressional changes in cytoskeleton-and synaptic plasticity-associated proteins in rat brain six months after withdrawal from morphine
Z Drastichova, L Hejnova, R Moravcova, J Novotny - Life, 2021 - mdpi.com
Drug withdrawal is associated with abstinence symptoms including deficits in cognitive
functions that may persist even after prolonged discontinuation of drug intake. Cognitive …
functions that may persist even after prolonged discontinuation of drug intake. Cognitive …