The clinical manifestations, molecular mechanisms and treatment of craniosynostosis

E Stanton, M Urata, JF Chen… - Disease Models & …, 2022 - journals.biologists.com
Craniosynostosis is a major congenital craniofacial disorder characterized by the premature
fusion of cranial suture (s). Patients with severe craniosynostosis often have impairments in …

The current regenerative medicine approaches of craniofacial diseases: A narrative review

E Tahmasebi, M Mohammadi, M Alam… - Frontiers in Cell and …, 2023 - frontiersin.org
Craniofacial deformities (CFDs) develop following oncological resection, trauma, or
congenital disorders. Trauma is one of the top five causes of death globally, with rates …

Clinical interest of molecular study in cases of isolated midline craniosynostosis

F Di Rocco, M Rossi, I Verlut, A Szathmari… - European Journal of …, 2023 - nature.com
In some cases of infants with apparently isolated single-suture synostosis, an underlying
variant can be found. We aimed to determine the molecular substratum in isolated sagittal …

Polarized M2 macrophages induced by mechanical stretching modulate bone regeneration of the craniofacial suture for midfacial hypoplasia treatment

W Liang, P Ding, J Qian, G Li, E Lu, Z Zhao - Cell and Tissue Research, 2021 - Springer
The underlying mechanism of the trans-sutural distraction osteogenesis (TSDO) technique
as an effective treatment that improves the symptoms of midfacial hypoplasia syndromes is …

Calvarial vault remodeling including pterional decompression for the treatment of nonsyndromic scaphocephaly patients: technical note and retrospective case series

V Matthijs, J Vandersteene, E Baert - Journal of Neurosurgery: Pediatrics, 2023 - thejns.org
OBJECTIVE Surgical techniques to correct scaphocephaly often rely on the implantation of
foreign material and/or postoperative helmet therapy and possibly result in minimal …

Outcomes of the early endoscopic-assisted suturectomy for treatment of multisuture craniosynostosis

O Yousefi, R Taheri, M Sabahi, RA Reynolds… - Neurosurgical …, 2023 - Springer
To present the outcomes and adverse events associated with the endoscopic-assisted,
minimally invasive suturectomy in patients with multisuture synostosis. This retrospective …

Sutural fibroblasts exhibit the function of vascular endothelial cells upon mechanical strain

G Li, W Liang, P Ding, Z Zhao - Archives of Biochemistry and Biophysics, 2021 - Elsevier
Midfacial hypoplasia is a type of facial dysplasia. The technique of trans-sutural distraction
osteogenesis promotes midface growth so as to ameliorate this symptom. In the process of …

The Role of Gli1+ Mesenchymal Stem Cells in Craniofacial Development and Disease Treatment

W Li, H Jiang, L Hu, T Shen… - Journal of Oral …, 2025 - Wiley Online Library
Objective This review summarises the role of Gli1+ (Glioma‐associated oncogene
homologue 1) mesenchymal stem cells in craniofacial growth and development or tissue …

Results from genetic studies in patients affected with craniosynostosis: clinical and molecular aspects

E Bukowska-Olech, A Sowińska-Seidler… - Frontiers in Molecular …, 2022 - frontiersin.org
Background: Craniosynostosis (CS) represents a highly heterogeneous genetic condition
whose genetic background has not been yet revealed. The abnormality occurs either in …

3D printing in pediatric neurosurgery: experimental study of a novel approach using biodegradable materials

R Mai, V Popov, E Mishina, E Osidak - Child's Nervous System, 2024 - Springer
Purpose 3D printing technologies have become an integral part of modern life, and the most
routinely used materials in reconstructive surgery in children are biodegradable materials …