The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells,
strategically situated between the photoreceptors and the choroid, is the primary caretaker of …

There is an urgency to find new treatment strategies that could prevent or delay the onset or
progression of AMD. Different classes of lipids and lipoproteins metabolism genes have …

Age-related macular degeneration (AMD) is a disease that affects the macula–the central
part of the retina. It is a leading cause of irreversible vision loss in the elderly. AMD onset is …

Neutrophils are the most abundant immune cell type in the blood and constitute the first line
of defense against invading pathogens. Despite their important role in many diseases, they …

The three interacting components of the outer blood-retinal barrier are the retinal pigment
epithelium (RPE), choriocapillaris, and Bruch's membrane, the extracellular matrix that lies …

Purpose The RPE cell line ARPE-19 provides a dependable and widely used alternative to
native RPE. However, replication of the native RPE phenotype becomes more difficult …

RPE cells are the most actively phagocytic cells in the human body. In the eye, RPE cells
face rod and cone photoreceptor outer segments at all times but contribute to shedding and …

Controlling the differentiation of human pluripotent stem cells is the goal of many
laboratories, both to study normal human development and to generate cells for …

Pigmented ocular tissues contain melanin within the intracellular melanosomes. Drugs bind
to melanin at varying extent that ranges from no binding to extensive binding. Binding may …

Human RPE cell lines, especially the ARPE-19 cell line, are widely-used in eye research, as
well as general epithelial cell studies. In comparison with primary RPE cells, they offer …