The rise of boron-containing compounds: advancements in synthesis, medicinal chemistry, and emerging pharmacology

RJ Grams, WL Santos, IR Scorei… - Chemical …, 2024 - ACS Publications
Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …

Recent developments of BODIPY-based colorimetric and fluorescent probes for the detection of reactive oxygen/nitrogen species and cancer diagnosis

VN Nguyen, J Ha, M Cho, H Li, KMK Swamy… - Coordination Chemistry …, 2021 - Elsevier
Boron-dipyrromethene (BODIPY) platforms have been recognized as potential candidates
for a wide range of applications, especially for constructing fluorescent probes due to their …

[HTML][HTML] BODIPY-based molecules for biomedical applications

S Das, S Dey, S Patra, A Bera, T Ghosh, B Prasad… - Biomolecules, 2023 - mdpi.com
BODIPY (4, 4-difluoro-4-bora-3a, 4a-diaza-s-indacene) derivatives have attracted attention
as probes in applications like imaging and sensing due to their unique properties like (1) …

BODIPY-based probes for hypoxic environments

L Gai, Y Liu, Z Zhou, H Lu, Z Guo - Coordination Chemistry Reviews, 2023 - Elsevier
Hypoxic environment is an important feature of solid tumors, which comes from the
imbalance of oxygen supply and consumption. Over the past few years, substantial progress …

Application of multifunctional small molecule fluorescent probe BODIPY in life science

L Yuan, Y Su, H Cong, B Yu, Y Shen - Dyes and Pigments, 2023 - Elsevier
BODIPY and its derivative multifunctional small molecule probes have become the darlings
in the field of biomedical materials due to its unique molecular structure, high brightness …

[HTML][HTML] BODIPYs in PDT: A Journey through the Most Interesting Molecules Produced in the Last 10 Years

MC Malacarne, MB Gariboldi, E Caruso - International Journal of …, 2022 - mdpi.com
Over the past 30 years, photodynamic therapy (PDT) has shown great development. In the
clinical setting the few approved molecules belong almost exclusively to the porphyrin …

Recent progress in the design principles, sensing mechanisms, and applications of small-molecule probes for nitroreductases

YL Qi, L Guo, LL Chen, H Li, YS Yang, AQ Jiang… - Coordination Chemistry …, 2020 - Elsevier
As one of the most representative hypoxic enzymes, nitroreductases (NTRs) play
momentous roles in malignant tumor progression, metastasis, invasion and angiogenesis …

Precise monitoring and assessing treatment response of sepsis-induced acute lung hypoxia with a nitroreductase-activated Golgi-targetable fluorescent probe

Z Tang, Z Yan, L Gong, L Zhang, X Yin, J Sun… - Analytical …, 2022 - ACS Publications
Sepsis-induced acute lung injury (ALI) is mostly attributed to an outbreak of reactive oxygen
species (ROS), which makes leukocytes infiltrate into the lung and results in lung hypoxia …

Functional materials for subcellular targeting strategies in cancer therapy: progress and prospects

Y Cheng, Z Qu, Q Jiang, T Xu, H Zheng, P Ye… - Advanced …, 2023 - Wiley Online Library
Neoadjuvant and adjuvant therapies have made significant progress in cancer treatment.
However, tumor adjuvant therapy still faces challenges due to the intrinsic heterogeneity of …

Engineering BODIPY-based near-infrared nanoparticles with large Stokes shifts and aggregation-induced emission characteristics for organelle specific bioimaging

X Guo, B Tang, Q Wu, W Bu, F Zhang, C Yu… - Journal of Materials …, 2022 - pubs.rsc.org
Lipid droplets (LDs) and lysosomes, as two important subcellular organelles, play specific
and indispensable roles in various cellular processes. The development of efficient LD-and …