Adipose tissue dysfunction as determinant of obesity-associated metabolic complications
Obesity is a critical risk factor for the development of type 2 diabetes (T2D), and its
prevalence is rising worldwide. White adipose tissue (WAT) has a crucial role in regulating …
prevalence is rising worldwide. White adipose tissue (WAT) has a crucial role in regulating …
Adipogenesis and metabolic health
AL Ghaben, PE Scherer - Nature reviews Molecular cell biology, 2019 - nature.com
Obesity is characterized by increased adipose tissue mass and has been associated with a
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …
PPARγ signaling and metabolism: the good, the bad and the future
Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear
receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral …
receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral …
Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?
Mesenchymal stem cells (MSCs), a non-hematopoietic stem cell population first discovered
in bone marrow, are multipotent cells capable of differentiating into mature cells of several …
in bone marrow, are multipotent cells capable of differentiating into mature cells of several …
[HTML][HTML] Metabolism disrupting chemicals and metabolic disorders
The recent epidemics of metabolic diseases, obesity, type 2 diabetes (T2D), liver lipid
disorders and metabolic syndrome have largely been attributed to genetic background and …
disorders and metabolic syndrome have largely been attributed to genetic background and …
Forming functional fat: a growing understanding of adipocyte differentiation
Adipose tissue, which is primarily composed of adipocytes, is crucial for maintaining energy
and metabolic homeostasis. Adipogenesis is thought to occur in two stages: commitment of …
and metabolic homeostasis. Adipogenesis is thought to occur in two stages: commitment of …
Browning of the white adipose tissue regulation: New insights into nutritional and metabolic relevance in health and diseases
SA Machado, G Pasquarelli-do-Nascimento… - Nutrition & …, 2022 - Springer
Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …
health and homeostasis. Although white adipose tissue and brown adipose tissue are …
Emerging role of tumor cell plasticity in modifying therapeutic response
Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …
have proposed that acquisition of resistance may result from genetic mutations. However …
[HTML][HTML] PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation
Cells are constantly exposed to a large variety of lipids. Traditionally, these molecules were
thought to serve as simple energy storing molecules. More recently it has been realized that …
thought to serve as simple energy storing molecules. More recently it has been realized that …
Analysis of association between vitamin D deficiency and insulin resistance
I Szymczak-Pajor, A Śliwińska - Nutrients, 2019 - mdpi.com
Recent evidence revealed extra skeleton activity of vitamin D, including prevention from
cardiometabolic diseases and cancer development as well as anti-inflammatory properties …
cardiometabolic diseases and cancer development as well as anti-inflammatory properties …