Molecular mechanism and regulation of autophagy and its potential role in epilepsy
H Zhu, W Wang, Y Li - Cells, 2022 - mdpi.com
Autophagy is an evolutionally conserved degradation mechanism for maintaining cell
homeostasis whereby cytoplasmic components are wrapped in autophagosomes and …
homeostasis whereby cytoplasmic components are wrapped in autophagosomes and …
[HTML][HTML] Mini-review: Synaptojanin 1 and its implications in membrane trafficking
This mini-review aims to summarize a growing body of literature on synaptojanin 1 (Synj1), a
phosphoinositide phosphatase that was initially known to have a prominent role in synaptic …
phosphoinositide phosphatase that was initially known to have a prominent role in synaptic …
Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9
Autophagy is a cellular degradation pathway essential for neuronal health and function.
Autophagosome biogenesis occurs at synapses, is locally regulated, and increases in …
Autophagosome biogenesis occurs at synapses, is locally regulated, and increases in …
Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates
Ectopic expression in fibroblasts of synapsin 1 and synaptophysin is sufficient to generate
condensates of vesicles highly reminiscent of synaptic vesicle (SV) clusters and with liquid …
condensates of vesicles highly reminiscent of synaptic vesicle (SV) clusters and with liquid …
The endo-lysosomal system in Parkinson's disease: Expanding the horizon
Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease, and its prevalence is increasing with age. A wealth of genetic evidence …
Alzheimer's disease, and its prevalence is increasing with age. A wealth of genetic evidence …
Orchestrating vesicular and nonvesicular membrane dynamics by intrinsically disordered proteins
Compartmentalization by membranes is a common feature of eukaryotic cells and serves to
spatiotemporally confine biochemical reactions to control physiology. Membrane‐bound …
spatiotemporally confine biochemical reactions to control physiology. Membrane‐bound …
Neuromelanin‐MRI to quantify and track nigral depigmentation in Parkinson's disease: A multicenter longitudinal study using template‐based standardized analysis
Background Clinical diagnosis and monitoring of Parkinson's disease (PD) remain
challenging because of the lack of an established biomarker. Neuromelanin‐magnetic …
challenging because of the lack of an established biomarker. Neuromelanin‐magnetic …
Molecular mechanism of cognitive impairment associated with Parkinson's disease: A stroke perspective
Parkinson's disease (PD) is a common neurological illness that causes several motor and
non-motor symptoms, most characteristically limb tremors and bradykinesia. PD is a slowly …
non-motor symptoms, most characteristically limb tremors and bradykinesia. PD is a slowly …
Impaired neuronal activity and differential gene expression in STXBP1 encephalopathy patient iPSC-derived GABAergic neurons
E Ichise, T Chiyonobu, M Ishikawa… - Human molecular …, 2021 - academic.oup.com
Abstract Syntaxin-binding protein 1 (STXBP1; also called MUNC18–1), encoded by
STXBP1, is an essential component of the molecular machinery that controls synaptic …
STXBP1, is an essential component of the molecular machinery that controls synaptic …
Synaptic vesicle characterization of iPSC-derived dopaminergic neurons provides insight into distinct secretory vesicle pools
K Fujise, J Mishra, MS Rosenfeld, NM Rafiq - npj Parkinson's Disease, 2025 - nature.com
The dysfunction of dopaminergic (DA) neurons is central to Parkinson's disease. Distinct
synaptic vesicle (SV) populations, differing in neurotransmitter content (dopamine vs …
synaptic vesicle (SV) populations, differing in neurotransmitter content (dopamine vs …