Bidirectional cargo transport: moving beyond tug of war
WO Hancock - Nature reviews Molecular cell biology, 2014 - nature.com
Vesicles, organelles and other intracellular cargo are transported by kinesin and dynein
motors, which move in opposite directions along microtubules. This bidirectional cargo …
motors, which move in opposite directions along microtubules. This bidirectional cargo …
Structure and mechanics of dynein motors
Dyneins make up a family of AAA+ motors that move toward the minus end of microtubules.
Cytoplasmic dynein is responsible for transporting intracellular cargos in interphase cells …
Cytoplasmic dynein is responsible for transporting intracellular cargos in interphase cells …
Tug-of-war in motor protein ensembles revealed with a programmable DNA origami scaffold
Cytoplasmic dynein and kinesin-1 are microtubule-based motors with opposite polarity that
transport a wide variety of cargo in eukaryotic cells. Many cellular cargos demonstrate …
transport a wide variety of cargo in eukaryotic cells. Many cellular cargos demonstrate …
[HTML][HTML] Molecular adaptations allow dynein to generate large collective forces inside cells
Many cellular processes require large forces that are generated collectively by multiple
cytoskeletal motor proteins. Understanding how motors generate force as a team is therefore …
cytoskeletal motor proteins. Understanding how motors generate force as a team is therefore …
The mammalian dynein–dynactin complex is a strong opponent to kinesin in a tug-of-war competition
Kinesin and dynein motors transport intracellular cargos bidirectionally by pulling them in
opposite directions along microtubules, through a process frequently described as a 'tug of …
opposite directions along microtubules, through a process frequently described as a 'tug of …
Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway
Autophagy is a degradative pathway required to maintain homeostasis. Neuronal
autophagosomes form constitutively at the axon terminal and mature via lysosomal fusion …
autophagosomes form constitutively at the axon terminal and mature via lysosomal fusion …
Getting around the cell: physical transport in the intracellular world
Eukaryotic cells face the challenging task of transporting a variety of particles through the
complex intracellular milieu in order to deliver, distribute, and mix the many components that …
complex intracellular milieu in order to deliver, distribute, and mix the many components that …
Stochastic mechano-chemical kinetics of molecular motors: a multidisciplinary enterprise from a physicist's perspective
D Chowdhury - Physics Reports, 2013 - Elsevier
A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …
MINFLUX reveals dynein step** in live neurons
Dynein is the primary molecular motor responsible for retrograde intracellular transport of a
variety of cargoes, performing successive nanometer-sized steps within milliseconds. Due to …
variety of cargoes, performing successive nanometer-sized steps within milliseconds. Due to …
Hook is an adapter that coordinates kinesin-3 and dynein cargo attachment on early endosomes
Bidirectional membrane trafficking along microtubules is mediated by kinesin-1, kinesin-3,
and dynein. Several organelle-bound adapters for kinesin-1 and dynein have been reported …
and dynein. Several organelle-bound adapters for kinesin-1 and dynein have been reported …