The prevalence of obesity-related glomerulopathy is increasing in parallel with the
worldwide obesity epidemic. Glomerular hypertrophy and adaptive focal segmental …

During aging, body adiposity increases with changes in the metabolism of lipids and their
metabolite levels. Considering lipid metabolism, excess adiposity with increased lipotoxicity …

There is very limited human renal sodium gradient-dependent glucose transporter protein
(SGLT2) mRNA and protein expression data reported in the literature. The first aim of this …

Overall excess of fat, usually defined by the body mass index, is associated with metabolic
(eg. glucose intolerance, type 2 diabetes mellitus (T2DM), dyslipidemia) and non-metabolic …

Background With the rising global prevalence of fatty liver disease related to metabolic
dysfunction, the association of this common liver condition with chronic kidney disease …

The possible link between nonalcoholic fatty liver disease and chronic kidney disease
(CKD) recently has attracted considerable scientific interest. Accumulating clinical evidence …

The average of overweight individual can have differential fat depots in target organs or
specific compartments of the body. This ectopic fat distribution may be more of a predictive …

Disturbances in fatty acid metabolism in adipose tissue, liver, skeletal muscle, gut and
pancreas play an important role in the development of insulin resistance, impaired glucose …

Background & Aims Non-alcoholic fatty liver disease (NAFLD) has been associated with
chronic kidney disease (CKD), but cohort studies are limited. We investigated the …

The transcription factor EB (TFEB) regulates the expression of target genes bearing the
Coordinated Lysosomal Expression and Regulation (CLEAR) motif, thereby modulating …