Bridging structural and cell biology with cryo-electron microscopy
E Nogales, J Mahamid - Nature, 2024 - nature.com
Most life scientists would agree that understanding how cellular processes work requires
structural knowledge about the macromolecules involved. For example, deciphering the …
structural knowledge about the macromolecules involved. For example, deciphering the …
Learning structural heterogeneity from cryo-electron sub-tomograms with tomoDRGN
BM Powell, JH Davis - Nature Methods, 2024 - nature.com
Cryo-electron tomography (cryo-ET) enables observation of macromolecular complexes in
their native, spatially contextualized cellular environment. Cryo-ET processing software to …
their native, spatially contextualized cellular environment. Cryo-ET processing software to …
Chemical strategies for antisense antibiotics
MJ Pals, A Lindberg, WA Velema - Chemical Society Reviews, 2024 - pubs.rsc.org
Antibacterial resistance is a severe threat to modern medicine and human health. To stay
ahead of constantly-evolving bacteria we need to expand our arsenal of effective antibiotics …
ahead of constantly-evolving bacteria we need to expand our arsenal of effective antibiotics …
The Nucleic Acid Knowledgebase: a new portal for 3D structural information about nucleic acids
Abstract The Nucleic Acid Knowledgebase (nakb. org) is a new data resource, updated
weekly, for experimentally determined 3D structures containing DNA and/or RNA nucleic …
weekly, for experimentally determined 3D structures containing DNA and/or RNA nucleic …
The reduction of FIB damage on cryo-lamella by lowering energy of ion beam revealed by a quantitative analysis
Focused ion beam (FIB) is widely used for thinning frozen cells to produce lamellae for cryo-
electron microscopy imaging and for protein structures study in vivo. However, FIB damages …
electron microscopy imaging and for protein structures study in vivo. However, FIB damages …
Rumicidins are a family of mammalian host-defense peptides plugging the 70S ribosome exit tunnel
PV Panteleev, EB Pichkur, RN Kruglikov… - Nature …, 2024 - nature.com
The antimicrobial resistance crisis along with challenges of antimicrobial discovery revealed
the vital necessity to develop new antibiotics. Many of the animal proline-rich antimicrobial …
the vital necessity to develop new antibiotics. Many of the animal proline-rich antimicrobial …
Structural and quantum chemical basis for OCP-mediated quenching of phycobilisomes
Cyanobacteria use large antenna complexes called phycobilisomes (PBSs) for light
harvesting. However, intense light triggers non-photochemical quenching, where the orange …
harvesting. However, intense light triggers non-photochemical quenching, where the orange …
Principles of ion binding to RNA inferred from the analysis of a 1.55 Å resolution bacterial ribosome structure – Part I: Mg2+
F Leonarski, A Henning-Knechtel… - Nucleic Acids …, 2025 - academic.oup.com
The importance of Mg2+ ions for RNA structure and function cannot be overstated. Several
attempts were made to establish a comprehensive Mg2+ binding site classification …
attempts were made to establish a comprehensive Mg2+ binding site classification …
CheckMyMetal (CMM): validating metal-binding sites in X-ray and cryo-EM data
Identifying and characterizing metal-binding sites (MBS) within macromolecular structures is
imperative for elucidating their biological functions. CheckMyMetal (CMM) is a web based …
imperative for elucidating their biological functions. CheckMyMetal (CMM) is a web based …
Uncovering protein ensembles: automated multiconformer model building for X-ray crystallography and cryo-EM
In their folded state, biomolecules exchange between multiple conformational states that are
crucial for their function. Traditional structural biology methods, such as X-ray …
crucial for their function. Traditional structural biology methods, such as X-ray …