Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical,
biological, and chemical signals to embraced cells. Increasing evidence suggests that …

Hippo effectors YAP/TAZ act as on–off mechanosensing switches by sensing modifications
in extracellular matrix (ECM) composition and mechanics. The regulation of their activity has …

Soft connective tissues at steady state are dynamic; resident cells continually read
environmental cues and respond to them to promote homeostasis, including maintenance of …

The talin-vinculin axis is a key mechanosensing component of cellular focal adhesions. How
talin and vinculin respond to forces and regulate one another remains unclear. By …

Stress fibers and focal adhesions are complex protein arrays that produce, transmit and
sense mechanical tension. Evidence accumulated over many years led to the conclusion …

Simple Summary The cytoskeleton is a network of protein fibres within cells that provide
structure and support intracellular transport. Focal adhesions are protein complexes …

Cell migration affects all morphogenetic processes and contributes to numerous diseases,
including cancer and cardiovascular disease. For most cells in most environments …

For an epithelium to provide a protective barrier, it must maintain homeostatic cell numbers
by matching the number of dividing cells with the number of dying cells. Although …

Cell adhesions to the extracellular matrix (ECM) are necessary for morphogenesis, immunity
and wound healing,. Focal adhesions are multifunctional organelles that mediate cell–ECM …