Malaria is a devastating infectious disease that is caused by blood-borne apicomplexan
parasites of the genus Plasmodium. These pathogens have a complex lifecycle, which …

Toxoplasma gondii and Plasmodium falciparum are important human pathogens. These
parasites and many of their apicomplexan relatives undergo a complex developmental …

Malaria is caused by Plasmodium parasites that proliferate in the bloodstream. During each
replication cycle, some parasites differentiate into gametocytes, the only forms able to infect …

The life cycles of many parasites involve transitions between disparate host species,
requiring these parasites to go through multiple developmental stages adapted to each of …

Commitment to and completion of sexual development are essential for malaria parasites
(protists of the genus Plasmodium) to be transmitted through mosquitoes. The molecular …

The malaria parasite Plasmodium falciparum has a great capacity for evolutionary
adaptation to evade host immunity and develop drug resistance. Current understanding of …

Clonally variant expression of surface antigens allows the malaria parasite Plasmodium
falciparum to evade immune recognition during blood stage infection and secure malaria …

The primary antigenic and virulence determinant of the human malaria parasite Plasmodium
falciparum is a variant surface protein called PfEMP1. Different forms of PfEMP1 are …

Underlying the development of malaria parasites within erythrocytes and the resulting
pathogenicity is a hardwired program that secures proper timing of gene transcription and …

Due to their remarkable parasitocidal activity, artemisinins represent the key components of
first-line therapies against Plasmodium falciparum malaria. However, the decline in efficacy …