Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Recent progress in fluorescence imaging allows neuroscientists to observe the dynamics of
thousands of individual neurons, identified genetically or by their connectivity, across …

Optical imaging in the second near-infrared window (NIR-II, 1,000–1,700 nm) holds great
promise for non-invasive in vivo detection. However, real-time dynamic multiplexed imaging …

Video-based screening of pooled libraries is a powerful approach for directed evolution of
biosensors because it enables selection along multiple dimensions simultaneously from …

Neuronal activity in the brain gives rise to transmembrane currents that can be measured in
the extracellular medium. Although the major contributor of the extracellular signal is the …

A central goal in neuroscience is to determine how the brain's neuronal circuits generate
perception, cognition and emotions and how these lead to appropriate behavioural actions …

Genetically encoded calcium indicators for visualizing dynamic cellular activity have greatly
expanded our understanding of the brain. However, owing to the light-scattering properties …

Extracting neuronal spiking activity from large-scale two-photon recordings remains
challenging, especially in mammals in vivo, where large noises often contaminate the …

With the booming of information technology, considerable progress has been witnessed in
information storage carriers, accompanied by soaring storage capacity. 3D codes as an …

Monitoring neuronal electrical activity using fluorescent protein-based voltage sensors has
been limited by small response magnitudes and slow kinetics of existing probes. Here we …