Impacts of bioinformatics to medicinal chemistry
KC Chou - Medicinal chemistry, 2015 - ingentaconnect.com
Facing the explosive growth of biological sequence data, such as those of protein/peptide
and DNA/RNA, generated in the post-genomic age, many bioinformatical and mathematical …
and DNA/RNA, generated in the post-genomic age, many bioinformatical and mathematical …
Some remarks on protein attribute prediction and pseudo amino acid composition
KC Chou - Journal of theoretical biology, 2011 - Elsevier
With the accomplishment of human genome sequencing, the number of sequence-known
proteins has increased explosively. In contrast, the pace is much slower in determining their …
proteins has increased explosively. In contrast, the pace is much slower in determining their …
SubMito-XGBoost: predicting protein submitochondrial localization by fusing multiple feature information and eXtreme gradient boosting
Motivation Mitochondria are an essential organelle in most eukaryotes. They not only play
an important role in energy metabolism but also take part in many critical cytopathological …
an important role in energy metabolism but also take part in many critical cytopathological …
An unprecedented revolution in medicinal chemistry driven by the progress of biological science
KC Chou - Current topics in medicinal chemistry, 2017 - ingentaconnect.com
The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat
various diseases and extend human beings' life as long as possible. Human being is a …
various diseases and extend human beings' life as long as possible. Human being is a …
Pseudo nucleotide composition or PseKNC: an effective formulation for analyzing genomic sequences
With the avalanche of DNA/RNA sequences generated in the post-genomic age, it is urgent
to develop automated methods for analyzing the relationship between the sequences and …
to develop automated methods for analyzing the relationship between the sequences and …
iDNA-Prot| dis: identifying DNA-binding proteins by incorporating amino acid distance-pairs and reduced alphabet profile into the general pseudo amino acid …
Playing crucial roles in various cellular processes, such as recognition of specific nucleotide
sequences, regulation of transcription, and regulation of gene expression, DNA-binding …
sequences, regulation of transcription, and regulation of gene expression, DNA-binding …
[HTML][HTML] Pse-in-One 2.0: an improved package of web servers for generating various modes of pseudo components of DNA, RNA, and protein sequences
B Liu, H Wu, KC Chou - Natural science, 2017 - scirp.org
Pse-in-One 2.0 is a package of web-servers evolved from Pse-in-One (Liu, B., Liu, F., Wang,
X., Chen, J. Fang, L. & Chou, KC Nucleic Acids Research, 2015, 43: W65-W71). In order to …
X., Chen, J. Fang, L. & Chou, KC Nucleic Acids Research, 2015, 43: W65-W71). In order to …
iPPI-Esml: an ensemble classifier for identifying the interactions of proteins by incorporating their physicochemical properties and wavelet transforms into PseAAC
A cell contains thousands of proteins. Many important functions of cell are carried out
through the proteins therein. Proteins rarely function alone. Most of their functions essential …
through the proteins therein. Proteins rarely function alone. Most of their functions essential …
Protein functional annotation of simultaneously improved stability, accuracy and false discovery rate achieved by a sequence-based deep learning
J Hong, Y Luo, Y Zhang, J Ying, W Xue… - Briefings in …, 2020 - academic.oup.com
Functional annotation of protein sequence with high accuracy has become one of the most
important issues in modern biomedical studies, and computational approaches of …
important issues in modern biomedical studies, and computational approaches of …
Pseudo amino acid composition and its applications in bioinformatics, proteomics and system biology
KC Chou - Current Proteomics, 2009 - ingentaconnect.com
With the avalanche of protein sequences generated in the post-genomic age, it is highly
desired to develop automated methods for efficiently identifying various attributes of …
desired to develop automated methods for efficiently identifying various attributes of …