Sarcopenia during COVID-19 lockdown restrictions: long-term health effects of short-term muscle loss

R Kirwan, D McCullough, T Butler, F Perez de Heredia… - Geroscience, 2020 - Springer
The COVID-19 pandemic is an extraordinary global emergency that has led to the
implementation of unprecedented measures in order to stem the spread of the infection …

Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies

EA Nunes, T Stokes, J McKendry… - … of Physiology-Cell …, 2022 - journals.physiology.org
Decreased skeletal muscle contractile activity (disuse) or unloading leads to muscle mass
loss, also known as muscle atrophy. The balance between muscle protein synthesis (MPS) …

Impact of sedentarism due to the COVID-19 home confinement on neuromuscular, cardiovascular and metabolic health: Physiological and pathophysiological …

M Narici, GD Vito, M Franchi, A Paoli… - European journal of …, 2021 - Taylor & Francis
The COVID-19 pandemic is an unprecedented health crisis as entire populations have been
asked to self-isolate and live in home-confinement for several weeks to months, which in …

Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity

NJ Pillon, BM Gabriel, L Dollet, JAB Smith… - Nature …, 2020 - nature.com
The molecular mechanisms underlying the response to exercise and inactivity are not fully
understood. We propose an innovative approach to profile the skeletal muscle transcriptome …

Treatment of NAFLD with diet, physical activity and exercise

M Romero-Gómez, S Zelber-Sagi, M Trenell - Journal of hepatology, 2017 - Elsevier
Lifestyle intervention can be effective when treating non-alcoholic fatty liver diseases
(NAFLD) patients. Weight loss decreases cardiovascular and diabetes risk and can also …

Reduced physical activity in young and older adults: metabolic and musculoskeletal implications

KA Bowden Davies, S Pickles… - Therapeutic …, 2019 - journals.sagepub.com
Background: Although the health benefits of regular physical activity and exercise are well
established and have been incorporated into national public health recommendations, there …

One week of bed rest leads to substantial muscle atrophy and induces whole-body insulin resistance in the absence of skeletal muscle lipid accumulation

ML Dirks, BT Wall, B Van De Valk, TM Holloway… - Diabetes, 2016 - diabetesjournals.org
Short (< 10 days) periods of muscle disuse, often necessary for recovery from illness or
injury, lead to various negative health consequences. The current study investigated …

Diagnosis and management of mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society

S Parikh, A Goldstein, MK Koenig, F Scaglia… - Genetics in …, 2015 - nature.com
Purpose: The purpose of this statement is to review the literature regarding mitochondrial
disease and to provide recommendations for optimal diagnosis and treatment. This …

Muscle atrophy in patients with Type 2 Diabetes Mellitus: roles of inflammatory pathways, physical activity and exercise

BD Perry, MK Caldow… - Exercise …, 2016 - pmc.ncbi.nlm.nih.gov
Muscle atrophy is caused by an imbalance in contractile protein synthesis and degradation
which can be triggered by various conditions including Type 2 Diabetes Mellitus (T2DM) …

Muscle atrophy induced by mechanical unloading: mechanisms and potential countermeasures

Y Gao, Y Arfat, H Wang, N Goswami - Frontiers in physiology, 2018 - frontiersin.org
Prolonged periods of skeletal muscle inactivity or mechanical unloading (bed rest, hindlimb
unloading, immobilization, spaceflight and reduced step) can result in a significant loss of …