The cohesin complex has a range of crucial functions in the cell. Cohesin is essential for
mediating chromatid cohesion during mitosis, for repair of double‐strand DNA breaks, and …

The cohesin complex, encoded by SMC3, SMC1A, RAD21, and STAG2, is a critical
regulator of DNA-loo** and gene expression. Over a decade has passed since recurrent …

Every cell of an organism shares the same genome; even so, each cellular lineage owns a
different transcriptome and proteome. The Polycomb group proteins (PcG) are essential …

The Polycomb Group (PcG) complex PRC1 represses transcription, forms condensates in
cells, and modifies chromatin architecture. These processes are connected through the …

Although the molecular rules governing genome organization are being quickly elucidated,
relatively few proteins regulating this process have been identified. To address this gap, we …

In mammalian cells, gene copy number is tightly controlled to maintain gene expression and
genome stability. However, a common molecular feature across cancer types is oncogene …