Combining radiotherapy and immunotherapy in lung cancer: can we expect limitations due to altered normal tissue toxicity?

F Wirsdörfer, S De Leve, V Jendrossek - International journal of molecular …, 2018 - mdpi.com
In recent decades, technical advances in surgery and radiotherapy, as well as
breakthroughs in the knowledge on cancer biology, have helped to substantially improve the …

Targeting the immunomodulatory CD73/adenosine system to improve the therapeutic gain of radiotherapy

S De Leve, F Wirsdörfer, V Jendrossek - Frontiers in immunology, 2019 - frontiersin.org
Extracellular adenosine is a potent endogenous immunosuppressive mediator critical to the
maintenance of homeostasis in various normal tissues including the lung. Adenosine is …

Re-evaluating the risk factors for radiation pneumonitis in the era of immunotherapy

F Chen, J Niu, M Wang, H Zhu, Z Guo - Journal of Translational Medicine, 2023 - Springer
As one of the common complications of radiotherapy, radiation pneumonia (RP) limits the
prognosis of patients. Therefore, better identifying the high-risk factors that lead to RP is …

Adaptive radiotherapy of lung cancer patients with pleural effusion or atelectasis

DS Møller, AA Khalil, MM Knap, L Hoffmann - Radiotherapy and oncology, 2014 - Elsevier
Background and purpose Changes in lung density due to atelectasis, pleural effusion and
pneumonia/pneumonitis are observed in lung cancer patients. These changes may be an …

Impact of heart and lung dose on early survival in patients with non-small cell lung cancer treated with chemoradiation

SL Tucker, A Liu, D Gomez, LL Tang, P Allen… - Radiotherapy and …, 2016 - Elsevier
Background and purpose To determine whether the impact of heart dose on early overall
survival (OS) reported in RTOG 0617 could be confirmed in an independent cohort …

New dose constraint reduces radiation-induced fatal pneumonitis in locally advanced non-small cell lung cancer patients treated with intensity-modulated …

AA Khalil, L Hoffmann, DS Moeller, KP Farr… - Acta …, 2015 - Taylor & Francis
Background. Intensity-modulated radiotherapy (IMRT) in locally advanced non-small cell
lung cancer (NSCLC) allows treatment of patients with large tumour volumes, but radiation …

Cone-beam-CT guided adaptive radiotherapy for locally advanced non-small cell lung cancer enables quality assurance and superior sparing of healthy lung

P Hoegen, C Lang, S Akbaba, P Häring… - Frontiers in …, 2020 - frontiersin.org
Purpose To evaluate the potential of cone-beam-CT (CB-CT) guided adaptive radiotherapy
(ART) for locally advanced non-small cell lung cancer (NSCLC) for sparing of surrounding …

Inclusion of functional information from perfusion SPECT improves predictive value of dose–volume parameters in lung toxicity outcome after radiotherapy for non …

KP Farr, JF Kallehauge, DS Møller, AA Khalil… - Radiotherapy and …, 2015 - Elsevier
Background and purpose To compare functional and standard dose–volume parameters as
predictors of postradiation pulmonary toxicity in lung cancer patients undergoing curative …

[HTML][HTML] Heart and lung doses are independent predictors of overall survival in esophageal cancer after chemoradiotherapy

C Xu, L Guo, Z Liao, Y Wang, X Liu, S Zhao… - Clinical and …, 2019 - Elsevier
Purpose To analyze associations between heart and lung dose and overall survival (OS) in
patients with esophageal cancer who received concurrent chemo-radiotherapy (CCRT) with …

Clinical outcome of image-guided adaptive radiotherapy in the treatment of lung cancer patients

M Tvilum, AA Khalil, DS Møller, L Hoffmann… - Acta …, 2015 - Taylor & Francis
Background. Adaptive strategy with daily online tumour match is a treatment option when
treating locally advanced lung cancer patients with curative intended radiotherapy (RT) …